Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

449 questions · 486 findings · 74 reviews

No studies found 34 · 7%GRADE not reported 73 · 15%Very low 127 · 26.1%Low 158 · 32.5%Moderate 69 · 14.2%High 25 · 5.1%

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Wound infection · lower gastrointestinal surgery

It is very uncertain whether early enteral nutrition within 24 hours of lower gastrointestinal… changes wound infection compared with later commencement (very low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Intraabdominal abscess · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in intraabdominal abscess compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Anastomotic leakage/dehiscence · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in anastomotic leakage/dehiscence compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Pneumonia · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in pneumonia (within hospital stay) compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

All‐cause mortality · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in mortality compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Vomiting · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in vomiting compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Nausea · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in nausea compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Nausea and vomiting · lower gastrointestinal surgery

It is very uncertain whether early enteral nutrition within 24 hours of lower gastrointestinal… changes nausea and vomiting compared with later commencement (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes hearing ‐ return to normal hearing Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes presence/persistence of OME Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes adverse event: persistent perforation compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Subgroup analyses: early vs standard initiation of kidney replacement therapy (KRT)

Death by AKI aetiology: non‐surgical causes · AKI

Subgroup analyses: early showed no clear difference in death by AKI aetiology: non‐surgical causes compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).

1 finding from 1 review

Subgroup analyses: early vs standard initiation of kidney replacement therapy (KRT)

Kidney recovery functionby KRT: continuous KRT · AKI

Subgroup analyses: early showed no clear difference in kidney recovery functionby KRT: continuous KRT compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).

1 finding from 1 review

Subgroup analyses: early vs standard initiation of kidney replacement therapy (KRT)

Kidney recovery functionby KRT: continuous and intermittent KRT · AKI

Subgroup analyses: early showed no clear difference in kidney recovery functionby KRT: continuous and intermittent KRT compared with standard initiation of kidney replacement therapy (KRT) (moderate certainty).

1 finding from 1 review

Unfavourable oral hygiene and dietary habits (frequent sweet/sugar consumption; low toothbrushing frequency in early childhood) vs Favourable oral hygiene and dietary habits

Caries development in permanent teeth · School children and adolescents (6-18 years) followed from primary dentition (baseline examination before 72 months of age)

Early-childhood oral hygiene and dietary habits show inconsistent associations with permanent-teeth caries, often losing significance after adjustment for past caries (2 studies; not pooled; not GRADE-rated).

1 finding from 1 review