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Evidence found and GRADE certainty

449 questions · 486 findings · 74 reviews

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No studies found 34 · 7%GRADE not reported 73 · 15%Very low 127 · 26.1%Low 158 · 32.5%Moderate 69 · 14.2%High 25 · 5.1%

Specialised early intervention (SEI) vs treatment

Mental state: 1b.Average end point score on various outcomes‐PANSS (medium‐term) ‐ Medium term ‐ PANSS general psychopathology end point score (low = favourable) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)
1 finding from 1 review

Specialised early intervention (SEI) vs treatment

Death: all‐cause mortality (assessed by proportion deceased at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in death: all‐cause mortality (assessed by proportion deceased at end… compared with treatment (low certainty).

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

Diagnosis of PTSD after treatment · various

It is very uncertain whether any early psychological intervention changes PTSD diagnosis: post‐treatment compared with waiting list/usual care (very low certainty).

1 finding from 1 review

Any early psychological intervention vs inactive control (usual care care, attention control, waitlist)

PTSD diagnosis · various

Any early psychological intervention may leads to lower PTSD diagnosis: 3–6 months compared with waiting list/usual care (low certainty).

2 findings from 1 review

Summary of findings table 1: comparison of operation types: early results of needle fasciotomy vs limited fasciectomy

DASH hand function score at 3 months Major outcome group 1 (hand function) (scores between 0 and 100, where 0 represents no impairment in hand function and 100 represents maximum impairment in hand function) · 125 hands in 121 participants with Dupuytren's disease of the fingers for early outcomes (van Rijssen 2006)
1 finding from 1 review

Early initiation of epidural analgesia vs Late initiation

Caesarean section · pregnant women (at term) requesting epidural analgesia in labour (regardless of whether the labour was spontaneous or induced)

Early initiation of epidural analgesia showed no clear difference in caesarean section compared with late initiation (high certainty).

1 finding from 1 review