Findings

What do systematic reviews say?

9 questions · 9 findings · 7 reviews

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No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 4 · 44.4%Low 2 · 22.2%Moderate 2 · 22.2%High 0 · 0%

Early ART vs delayed ART initiation

All‐cause mortality at 6 to 12 months · HIV‐positive people with cryptococcal meningitis

Early ART may leads to higher all‐cause mortality at 6 to 12 months compared with delayed ART initiation (low certainty).

1 finding from 1 review

Early versus delayed antiretroviral treatment in HIV‐positive people with cryptococcal meningitis 2018 · Cochrane Headline outcomes only
RR 1.42 [1.02, 1.97]
4 studies · 294 participants
Low

Early vs delayed laparoscopic appendicectomy

All‐cause mortality · paediatric participants with appendiceal abscess

1 finding from 1 review

Early versus delayed appendicectomy for appendiceal phlegmon or abscess 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Early vs delayed laparoscopic cholecystectomy

All‐cause mortality · people with biliary colic

It is very uncertain whether early changes mortality compared with delayed laparoscopic cholecystectomy (very low certainty).

1 finding from 1 review

Early versus delayed laparoscopic cholecystectomy for uncomplicated biliary colic 2013 · Cochrane Headline outcomes only
RR 0.38 [0.02, 9.03]
1 study · 75 participants
Very low

Early vs delayed open or laparoscopic appendicectomy

Mortality Median · paediatric and adult patients with appendiceal phlegmon

1 finding from 1 review

Early versus delayed appendicectomy for appendiceal phlegmon or abscess 2024 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 788 participants
Very low

Early vs delayed mobilisation

All‐cause mortality · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)

1 finding from 1 review

Interventions for treating proximal humeral fractures in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 92 participants
Very low

Early treatment vs expectant management

All‐cause mortality during hospital stay · preterm infants

Early treatment showed no clear difference in all‐cause mortality during hospital stay compared with expectant management (moderate certainty).

1 finding from 1 review

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
RR 0.8 [0.46, 1.39]
6 studies · 500 participants
Moderate

Very early treatment vs expectant management

All‐cause mortality during hospital stay · preterm infants

Very early treatment showed no clear difference in all‐cause mortality during hospital stay compared with expectant management (moderate certainty).

1 finding from 1 review

Early treatment versus expectant management of hemodynamically significant patent ductus arteriosus for preterm infants 2020 · Cochrane Headline outcomes only
RR 0.94 [0.58, 1.53]
7 studies · 384 participants
Moderate

Specialised early intervention (SEI) vs treatment

Death: all‐cause mortality (assessed by proportion deceased at end of treatment) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Specialised early intervention (SEI) showed no clear difference in death: all‐cause mortality (assessed by proportion deceased at end… compared with treatment (low certainty).

1 finding from 1 review

Specialised early intervention teams for recent‐onset psychosis 2020 · Cochrane Headline outcomes only
RR 0.21 [0.04, 1.2]
3 studies · 741 participants
Low

Early paracetamol vs placebo or no intervention

All‐cause mortality during hospital stay · preterm or low birth weight infants with PDA

The review found no eligible studies for this question.

1 finding from 1 review

Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found