It is very uncertain whether doxycycline changes treatment failure compared with tetracycline (very low certainty).
Doxycycline showed no clear difference in resolution of fever within 48 hours compared with tetracycline (low certainty).
The review found no eligible studies for this question.
The review found no eligible studies for this question.
Doxycycline may leads to higher bacteriological failure compared with quinolones (low certainty).
Doxycycline+Rifampicin probably leads to higher total treatment failure compared with doxycycline+Streptomycin (moderate certainty).
Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with doxycycline+Streptomycin (low certainty).
Doxycycline+Streptomycin showed no clear difference in total treatment failure compared with doxycycline+Gentamycin (low certainty).
It is very uncertain whether doxycycline+Streptomycin changes minor adverse drug reactions compared with doxycycline+Gentamycin (very low certainty).
Doxycycline+Rifampicin showed no clear difference in total treatment failure compared with quinolones+Rifampicin (moderate certainty).
Doxycycline+Rifampicin showed no clear difference in minor adverse drug reactions compared with quinolones+Rifampicin (low certainty).