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What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 2 reviews · Metabolic and Endocrine Disorders

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No studies found 7 · 33.3%GRADE not reported 0 · 0%Very low 10 · 47.6%Low 3 · 14.3%Moderate 1 · 4.8%High 0 · 0%

Adverse event outcomes for dietary combined with physical activity interventions vs usual care

All‐cause mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether diet plus physical activity changes all‐cause mortality compared with standard treatment (very low certainty).

1 finding from 1 review

Adverse event outcomes for dietary combined with physical activity interventions vs usual care

Development of type 2 diabetes · people at increased risk for developing type 2 diabetes

Diet plus physical activity probably leads to lower incidence of type 2 diabetes mellitus Diagnostic criteria: 3 trials… compared with standard treatment (moderate certainty).

1 finding from 1 review

Adverse event outcomes for dietary combined with physical activity interventions vs usual care

Cardiovascular mortality · people at increased risk for developing type 2 diabetes

It is very uncertain whether diet plus physical activity changes cardiovascular mortality compared with standard treatment (very low certainty).

1 finding from 1 review

Summary of findings table for metformin plus intensive diet and exercise vs intensive diet and exercise

Development of type 2 diabetes · people at increased risk for developing type 2 diabetes

It is very uncertain whether summary of findings table for metformin plus intensive diet and… changes incidence of type 2 diabetes mellitus (N) Diagnostic criteria: 2… compared with intensive diet and exercise (very low certainty).

1 finding from 1 review