Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 20 findings · 3 reviews

No studies found 6 · 30%GRADE not reported 0 · 0%Very low 3 · 15%Low 4 · 20%Moderate 6 · 30%High 1 · 5%

Dextrose gel vs placebo

Receipt of treatment for hypoglycaemia during initial hospital stay (investigator‐defined, any treatment ‐ oral dextrose gel, intravenous dextrose, or other drug therapy) during initial hospital stay (yes/no) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in receipt of treatment for hypoglycaemia during initial hospital stay… compared with placebo (moderate certainty).

1 finding from 1 review

Dextrose gel vs placebo

Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in major neurological disability at 2 years of age (Defined as any of… compared with placebo (low certainty).

1 finding from 1 review

Dextrose gel vs placebo

Receipt of intravenous treatment for hypoglycaemia (yes/no) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in receipt of intravenous treatment for hypoglycaemia (yes/no) compared with placebo (moderate certainty).

1 finding from 1 review

Dextrose gel vs placebo

Adverse events# (e.g. choking or vomiting at time of administration) · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in adverse events# (e.g. choking or vomiting at time of administration) compared with placebo (moderate certainty).

1 finding from 1 review

Dextrose gel vs placebo

Separation from mother for treatment of hypoglycaemia · newborn infants at risk of neonatal hypoglycaemia

Dextrose gel showed no clear difference in separation from mother for treatment of hypoglycaemia (infant nursed… compared with placebo (low certainty).

1 finding from 1 review

Dextrose gel vs control

Correction of hypoglycaemia for each hypoglycaemic event before discharge home (investigator defined) · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in correction of hypoglycaemia for each hypoglycaemic event before… compared with control (moderate certainty).

1 finding from 1 review

Dextrose gel vs control

Major neurological disability at 2 years of age (Defined as any of the following: legal blindness, sensorineural deafness requiring hearing aids, moderate or severe cerebral palsy or developmental delay/intellectual impairment (developmental quoti... · newborn infants with hypoglycaemia

Oral dextrose gel showed no clear difference in major neurological disability at age 2 years or olderb Defined as… compared with control (low certainty).

1 finding from 1 review

Dextrose gel vs control

Receipt of intravenous treatment for hypoglycaemia (yes/no) · newborn infants with hypoglycaemia

It is very uncertain whether oral dextrose gel changes receipt of intravenous treatment for hypoglycaemia before discharge… compared with control (very low certainty).

1 finding from 1 review

Dextrose gel vs control

Breastfeeding (exclusive after discharge) ‐ not reported (WHO 2008 definition (yes/no)) · newborn infants with hypoglycaemia

Oral dextrose gel probably leads to higher exclusive breastfeeding after discharge (WHO 2008 definition (yes/no)) compared with control (moderate certainty).

1 finding from 1 review