Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

19 questions · 19 findings · 3 reviews

No studies found 4 · 21.1%GRADE not reported 1 · 5.3%Very low 7 · 36.8%Low 6 · 31.6%Moderate 1 · 5.3%High 0 · 0%

Dexmedetomidine vs control or placebo medications

Adverse event nausea and vomiting (0 to 24 hours) · adults undergoing brain surgery

Dexmedetomidine showed no clear difference in adverse event nausea and vomiting (0 to 24 hours) compared with control or placebo medications (low certainty).

1 finding from 1 review

Dexmedetomidine vs traditional sedative agents

Risk of delirium · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes risk of delirium compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Dexmedetomidine vs traditional sedative agents

Bradycardia · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes incidence of bradycardia compared with traditional sedative agents (very low certainty).

1 finding from 1 review

Dexmedetomidine vs traditional sedative agents

All‐cause mortality · Critically ill patients requiring long‐term sedation during mechanical ventilation

It is very uncertain whether dexmedetomidine changes mortality compared with traditional sedative agents (very low certainty).

1 finding from 1 review