Total mortality · people with primary hypertension
It is very uncertain whether combination therapy changes total mortality compared with monotherapy (very low certainty).
1 finding from 1 review
Cardiovascular mortality · people with primary hypertension
1 finding from 1 review
Cardiovascular events · people with primary hypertension
It is very uncertain whether combination therapy changes cardiovascular events compared with monotherapy (very low certainty).
1 finding from 1 review
Serious adverse events · people with primary hypertension
It is very uncertain whether combination therapy changes serious adverse events compared with monotherapy (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with primary hypertension
It is very uncertain whether combination therapy changes withdrawals due to adverse effects compared with monotherapy (very low certainty).
1 finding from 1 review
Overall survival (3 years) · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
It is very uncertain whether combination chemotherapy changes overall survival (3 years) compared with single‐agent chemotherapy (very low certainty).
1 finding from 1 review
Disease-free survival · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
It is very uncertain whether combination chemotherapy changes disease‐free survival (3 years) compared with single‐agent chemotherapy (very low certainty).
1 finding from 1 review
Complete response rate after preoperative chemoradiation (ypCR) · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy leads to higher complete response rate after preoperative chemoradiation (ypCR) compared with single‐agent chemotherapy (high certainty).
1 finding from 1 review
Toxicity ‐ early adverse events G3/4 · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy probably leads to higher toxicity ‐ early adverse events G3/4 compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
Metastases intra‐abdominal · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy showed no clear difference in metastases intra‐abdominal compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
Radiotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy probably leads to lower radiotherapy compliance compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
Chemotherapy compliance · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy leads to lower chemotherapy compliance compared with single‐agent chemotherapy (high certainty).
1 finding from 1 review
Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review
Surgical intervention · men with lower urinary tract symptoms secondary to benign prostatic obstruction
It is very uncertain whether combination therapy changes surgical intervention compared with alpha‐blockers (very low certainty).
1 finding from 1 review
Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review
QoL · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review
Adverse events · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Combination therapy showed no clear difference in adverse events compared with anticholinergics (moderate certainty).
1 finding from 1 review
AUR · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Combination therapy showed no clear difference in AUR compared with anticholinergics (low certainty).
1 finding from 1 review
Surgical intervention – not reported · men with lower urinary tract symptoms secondary to benign prostatic obstruction
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
QoL · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review