Adverse events · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Combination therapy showed no clear difference in adverse events compared with alpha‐blockers (low certainty).
1 finding from 1 review
AUR · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Combination therapy showed no clear difference in AUR compared with alpha‐blockers (low certainty).
1 finding from 1 review
Overall survival (3 years) · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
It is very uncertain whether combination chemotherapy changes overall survival (3 years) compared with single‐agent chemotherapy (very low certainty).
1 finding from 1 review
Disease-free survival · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
It is very uncertain whether combination chemotherapy changes disease‐free survival (3 years) compared with single‐agent chemotherapy (very low certainty).
1 finding from 1 review
Complete response rate after preoperative chemoradiation (ypCR) · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy leads to higher complete response rate after preoperative chemoradiation (ypCR) compared with single‐agent chemotherapy (high certainty).
1 finding from 1 review
Toxicity ‐ early adverse events G3/4 · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy probably leads to higher toxicity ‐ early adverse events G3/4 compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
Metastases intra‐abdominal · people with resectable stage II and III rectal cancer undergoing preoperative chemoradiation followed by surgery
Combination chemotherapy showed no clear difference in metastases intra‐abdominal compared with single‐agent chemotherapy (moderate certainty).
1 finding from 1 review
All‐cause mortality
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
M + GLP1‐A
2 findings from 1 review
M + DPP4‐I
It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + DPP4‐I compared with metformin plus another antidiabetic drug (very low certainty).
3 findings from 1 review
RR 2.21 [0.74, 6.58]
4 studies · 5093 participants
Very low
no estimate extracted
1 study · 64 participants
Very low
RR 1.32 [0.76, 2.28]
9 studies · 11694 participants
Low
M + thiazolidinedione
It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + thiazolidinedione compared with metformin plus another antidiabetic drug (very low certainty).
2 findings from 1 review
M + nateglinide
4 findings from 1 review
no estimate extracted
1 study · 233 participants
Very low
no estimate extracted
3 studies · 874 participants
Low
no estimate extracted
2 studies · 446 participants
Low
Show 1 more finding
M + SGLT2‐I
It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + SGLT2‐I compared with metformin plus another antidiabetic drug (very low certainty).
2 findings from 1 review
Health‐related quality of life
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Non‐fatal stroke
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All‐cause mortality · Kaposi sarcoma in children with HIV‐1 infection
It is very uncertain whether combination Chemotherapy + ART changes mortality compared with single Agent Chemotherapy + ART (very low certainty).
1 finding from 1 review
RR 0.38 [0.24, 0.58]
50 participants
Very low
Hospital admissions · Adults with acute asthma
Combination inhaled therapy probably leads to lower hospitalisation compared with SABA alone (moderate certainty).
1 finding from 1 review
Total adverse events · Adults with acute asthma
Combination inhaled therapy probably leads to higher total adverse events compared with SABA alone (moderate certainty).
1 finding from 1 review
FEV1 · Adults with acute asthma
1 finding from 1 review
Percent change FEV₁(%) · Adults with acute asthma
1 finding from 1 review