What do systematic reviews say?

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  No adverse events were reported. Six trials (673 participants) reported no adverse events from the use of chlorhexidine gel; one study (Rubio-Palau 2015) reported gastrointestinal discomfort (30, 18%), dizziness (10,…
  7 studies
  GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  No adverse events were reported in these two trials (Abu-Mostafa 2015; Hita-Iglesias 2008).
  2 studies
  GRADE not reported

Chlorhexidine gel (0.2%, intrasocket) vs Chlorhexidine mouthrinse

Chlorhexidine gel (0.2%, intrasocket) showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.12%) (low certainty).

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  RR 0.74 [0.46, 1.20]
  2 studies · 383 participants
  Low

Chlorhexidine gel (0.2%, intrasocket) vs placebo or no treatment

Chlorhexidine gel (0.2%, intrasocket) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  OR 0.44 [0.27, 0.71]
  7 studies · 753 participants
  Moderate

Chlorhexidine rinse (0.2%) pre- and post-extraction vs Chlorhexidine rinse (0.2%) post-extraction only

Chlorhexidine rinse (0.2%) pre- and post-extraction showed no clear difference in presence of dry socket compared with chlorhexidine rinse (0.2%) post-extraction only; GRADE not reported.

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  RR 0.58 [0.15, 2.17]
  1 study · 99 participants
  GRADE not reported

Chlorhexidine 0.2% socket irrigation (monoject syringe) vs Chlorhexidine 0.2% mouthrinse

Chlorhexidine 0.2% socket irrigation (monoject syringe) led to lower presence of dry socket compared with chlorhexidine 0.2% mouthrinse; GRADE not reported.

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  RR 0.26 [0.09, 0.71]
  1 study · 95 participants
  GRADE not reported

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) probably leads to lower presence of dry socket compared with placebo or no treatment (moderate certainty).

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  OR 0.38 [0.25, 0.58]
  6 studies · 1547 participants
  Moderate

Chlorhexidine rinse (0.12% and 0.2%, pre- and post-extraction) vs placebo or no treatment

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Follow-up: median 7 days
  3 trials reported no adverse events. 1 study reported adverse events (alterations in taste, bad taste, staining) in 24/62 in chlorhexidine group versus 0/40 in placebo group, Peto OR = 8.42 (95% CI 3.31 to 21.39). A…
  6 studies
  GRADE not reported