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What do systematic reviews say?

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Evidence found and GRADE certainty

7 questions · 8 findings · 1 reviews · Headline outcomes only

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 4 · 50%Low 4 · 50%Moderate 0 · 0%High 0 · 0%

CR oxycodone vs CR morphine

Constipation · adults with cancer‐related pain

It is very uncertain whether CR oxycodone changes constipation ‐ only English language studies (Event rate during… compared with CR morphine (very low certainty).

2 findings from 1 review

CR oxycodone vs CR morphine

Drowsiness/somnolence (Event rate during treatment, length of treatment varied across trials) · adults with cancer‐related pain

CR oxycodone showed no clear difference in drowsiness/somnolence (Event rate during treatment, length of… compared with CR morphine (low certainty).

1 finding from 1 review

CR oxycodone vs CR morphine

Nausea · adults with cancer‐related pain

CR oxycodone showed no clear difference in nausea (Event rate during treatment, length of treatment varied… compared with CR morphine (low certainty).

1 finding from 1 review

CR oxycodone vs CR morphine

Vomiting · adults with cancer‐related pain

It is very uncertain whether CR oxycodone changes vomiting (Event rate during treatment, length of treatment varied… compared with CR morphine (very low certainty).

1 finding from 1 review

CR oxycodone vs CR morphine

Quality of life · adults with cancer‐related pain

It is very uncertain whether CR oxycodone changes quality of life compared with CR morphine (very low certainty).

1 finding from 1 review

CR oxycodone vs CR morphine

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · adults with cancer‐related pain

CR oxycodone may leads to higher pain intensity (various pain intensity scales; SMD) compared with CR morphine (low certainty).

1 finding from 1 review