What do systematic reviews say?

Buffered vs non‐buffered crystalloid intravenous fluid

Buffered showed no clear difference in mortality (in‐hospital death and 30‐day mortality) compared with non‐buffered crystalloid intravenous fluid (low certainty).

• Perioperative administration of buffered versus non‐buffered crystalloid intravenous fluid to improve outcomes… 2017 · Cochrane Headline outcomes only
  OR 1.85 [0.37, 9.33]
  3 studies · 267 participants
  Low

Buffered vs non‐buffered crystalloid intravenous fluid

Buffered showed no clear difference in organ system failure ‐ renal insufficiency requiring support compared with non‐buffered crystalloid intravenous fluid (low certainty).

• Perioperative administration of buffered versus non‐buffered crystalloid intravenous fluid to improve outcomes… 2017 · Cochrane Headline outcomes only
  OR 0.82 [0.34, 1.98]
  4 studies · 267 participants
  Low

Buffered vs non‐buffered crystalloid intravenous fluid

• Perioperative administration of buffered versus non‐buffered crystalloid intravenous fluid to improve outcomes… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 720 participants
  Moderate

Buffered vs non‐buffered crystalloid intravenous fluid

• Perioperative administration of buffered versus non‐buffered crystalloid intravenous fluid to improve outcomes… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 530 participants
  Moderate