Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

125 questions · 130 findings · 16 reviews

No studies found 25 · 19.2%GRADE not reported 10 · 7.7%Very low 28 · 21.5%Low 29 · 22.3%Moderate 27 · 20.8%High 11 · 8.5%

Botulinum toxin plus conservative treatment vs conservative treatment

Recurrence of ITW post‐treatment Assessed by improvement in toe walking based on Gait Analysis Classification An increase indicates improvement (an improvement indicated by a change in downgrading of the severe or 3, moderate or 2, and mild or 1 c... · children with ITW gait
1 finding from 1 review

Botulinum toxin A (with and without casting) vs placebo (with and without casting)

Spasticity at 4‐12 weeks (measured by both Modified Ashworth Scale, 0‐5, at 12 weeks and Tardieu Scale, 0‐5, at 4 weeks) · adults with traumatic brain injury with spasticity in their arms (1 study) or calves (1 study)
1 finding from 1 review

Botulinum neurotoxin B vs placebo

Withdrawals due to adverse events · adults with cervical dystonia

Botulinum neurotoxin B showed no clear difference in proportion of withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Botulinum neurotoxin B vs placebo

Proportion of participants with adverse events · adults with cervical dystonia

It is very uncertain whether botulinum neurotoxin B changes proportion of participants with adverse events compared with placebo (very low certainty).

1 finding from 1 review