What do systematic reviews say?

Bisphosphonates vs placebo

Bisphosphonates showed no clear difference in number of participants who experienced side effects related to use… compared with placebo (low certainty).

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  RR 1.32 [0.91, 1.92]
  6 studies · 678 participants
  Low

Bisphosphonates vs placebo

Bisphosphonates probably leads to higher number of participants with change in bone pain (disappearance of… compared with placebo (moderate certainty).

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  RR 3.42 [1.31, 8.9]
  2 studies · 205 participants
  Moderate

Bisphosphonates vs placebo

It is very uncertain whether bisphosphonates changes number of participants who experienced radiologically‐confirmed… compared with placebo (very low certainty).

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  RR 0.89 [0.18, 4.31]
  4 studies · 356 participants
  Very low

Bisphosphonates vs placebo

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Bisphosphonates vs placebo

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Bisphosphonates vs placebo

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Bisphosphonates vs placebo

Bisphosphonates showed no clear difference in number of participants who withdrew due to adverse events compared with placebo (low certainty).

• Bisphosphonates for Paget's disease of bone in adults 2017 · Cochrane Headline outcomes only
  RR 1.01 [0.41, 2.52]
  6 studies · 517 participants
  Low

Bisphosphonates vs control

Bisphosphonates leads to lower incident vertebral fractures Radiographic compared with control (high certainty).

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  RR 0.57 [0.35, 0.91]
  12 studies · 1343 participants
  High

Bisphosphonates vs control

Bisphosphonates showed no clear difference in incident nonvertebral fractures Radiographic compared with control (low certainty).

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  RR 0.79 [0.47, 1.33]
  9 studies · 1245 participants
  Low

Bisphosphonates vs control

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  no estimate extracted
  23 studies · 2042 participants
  Moderate

Bisphosphonates vs control

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  no estimate extracted
  18 studies · 1665 participants
  Moderate

Bisphosphonates vs control

Bisphosphonates showed no clear difference in serious adverse events compared with control (low certainty).

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  RR 0.91 [0.74, 1.12]
  15 studies · 1703 participants
  Low

Bisphosphonates vs control

Bisphosphonates showed no clear difference in withdrawals due to adverse events compared with control (low certainty).

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  RR 1.06 [0.77, 1.47]
  15 studies · 1790 participants
  Low

Bisphosphonates vs control

• Bisphosphonates for steroid‐induced osteoporosis 2016 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported