It is very uncertain whether CHRONIC: Beta‐blockers changes hypotension compared with placebo (very low certainty).
Perioperative beta‐blockers probably leads to higher hypotension (within 30 days; as defined by study authors, minimum… compared with placebo or standard care (moderate certainty).
Systemic administration of beta‐blockers may leads to higher arterial hypotension and/or bradycardia requiring treatment compared with placebo or no treatment (low certainty).
Beta‐blockers showed no clear difference in total mortality compared with renin‐angiotensin system inhibitors (moderate certainty).
Beta‐blockers showed no clear difference in total cardiovascular disease compared with renin‐angiotensin system inhibitors (low certainty).
Beta‐blockers probably leads to higher total stroke compared with renin‐angiotensin system inhibitors (moderate certainty).
Beta‐blockers showed no clear difference in total coronary heart disease compared with renin‐angiotensin system inhibitors (low certainty).
Beta‐blockers probably leads to higher withdrawal due to adverse effect compared with renin‐angiotensin system inhibitors (moderate certainty).
Beta‐blockers may leads to lower cardiovascular mortality (RR) compared with placebo or no treatment (low certainty).
It is very uncertain whether beta‐blockers changes heart failure hospitalisation (RR) compared with placebo or no treatment (very low certainty).
Beta‐blockers showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (low certainty).
Beta‐blockers showed no clear difference in total mortality compared with placebo (moderate certainty).
Beta‐blockers showed no clear difference in withdrawal due to adverse effect compared with diuretics (low certainty).