The review found no eligible studies for this question.
Systemic administration of beta‐blockers may leads to lower rescue treatment with anti‐VEGF agents compared with placebo or no treatment (low certainty).
Systemic administration of beta‐blockers may leads to lower treatment with laser photocoagulation or cryotherapy compared with placebo or no treatment (low certainty).
Systemic administration of beta‐blockers showed no clear difference in progression to stage 2 with plus disease compared with placebo or no treatment (moderate certainty).
Systemic administration of beta‐blockers probably leads to lower progression to stage 3 ROP compared with placebo or no treatment (moderate certainty).
Systemic administration of beta‐blockers showed no clear difference in progression to stage 4 or 5 ROP compared with placebo or no treatment (moderate certainty).
Systemic administration of beta‐blockers may leads to higher arterial hypotension and/or bradycardia requiring treatment compared with placebo or no treatment (low certainty).