Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

98 questions · 102 findings · 13 reviews

No studies found 10 · 9.8%GRADE not reported 1 · 1%Very low 16 · 15.7%Low 45 · 44.1%Moderate 25 · 24.5%High 5 · 4.9%

Beta‐blockers vs placebo

Total cardiovascular disease

Beta‐blockers may leads to lower total cardiovascular disease compared with placebo (low certainty).

1 finding from 1 review

Beta‐blockers vs placebo

Total coronary heart disease

Beta‐blockers showed no clear difference in total coronary heart disease compared with placebo (moderate certainty).

1 finding from 1 review

Beta‐blockers vs placebo

Withdrawals due to adverse events

Beta‐blockers showed no clear difference in withdrawal due to adverse effect compared with placebo (low certainty).

1 finding from 1 review

Beta‐blockers vs diuretics

Total mortality

Beta‐blockers showed no clear difference in total mortality compared with diuretics (moderate certainty).

1 finding from 1 review

Beta‐blockers vs diuretics

Total cardiovascular disease

Beta‐blockers showed no clear difference in total cardiovascular disease compared with diuretics (moderate certainty).

1 finding from 1 review

Beta‐blockers vs diuretics

Total coronary heart disease

Beta‐blockers showed no clear difference in total coronary heart disease compared with diuretics (low certainty).

1 finding from 1 review

Beta‐blockers vs placebo, no treatment or surveillance only

Clinically important non‐fatal end point as defined byShores 1994(aortic dissection, aortic regurgitation, congestive heart failure, or cardiovascular surgery) · people with confirmed diagnosis of Marfan syndrome

Beta‐blockers showed no clear difference in clinically important non‐fatal end point as defined byShores… compared with placebo, no treatment or surveillance only (low certainty).

1 finding from 1 review