Cochrane · systematic review · CD011103
Beta‐blockers for preventing aortic dissection in Marfan syndrome
Koo, HK, Lawrence, KAK, Musini, VM · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
HeartAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
8
current version
GRADE rated
7
No studies
1
Included studies
NR
No studies 1 · 12.5%Ungraded 0 · 0%Very low 0 · 0%Low 7 · 87.5%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Beta‐blockers compared with placebo, no treatment or surveillance only for preventing aortic dissection in Marfan's syndrome
Population: people with confirmed diagnosis of Marfan syndrome
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Outcomes Beta‐blockers vs placebo, no treatment or surveillance only | no estimate extracted | NR | No studies |
All‐cause mortality Beta‐blockers vs placebo, no treatment or surveillance only | RR 0.24 [0.01, 4.75] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Clinically important non‐fatal end point as defined byShores 1994(aortic dissection, aortic regurgitation, congestive heart failure, or cardiovascular surgery) Beta‐blockers vs placebo, no treatment or surveillance only | RR 0.79 [0.37, 1.69] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Acute aortic dissection Beta‐blockers vs placebo, no treatment or surveillance only | RR 0.59 [0.12, 3.03] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Aortic regurgitation Beta‐blockers vs placebo, no treatment or surveillance only | RR 1.19 [0.18, 7.96] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Congestive heart failure Beta‐blockers vs placebo, no treatment or surveillance only | RR 1.19 [0.18, 7.96] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Cardiovascular surgery Beta‐blockers vs placebo, no treatment or surveillance only | RR 0.59 [0.12, 3.03] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |
Aortic root diameter > 6 cm Beta‐blockers vs placebo, no treatment or surveillance only | RR 1.19 [0.08, 18.24] | 1 study · 70 participants | Low Downgraded: risk of bias, imprecision |