Tranquillisation or asleep: sedation ‐ medium termNumber of participants sedated · psychosis‐induced aggression or agitation
It is very uncertain whether benzodiazepines plus antipsychotics changes tranquillisation or asleep: sedation ‐ medium termNumber of… compared with antihistamines plus antipsychotics (very low certainty).
1 finding from 1 review
Global state: no improvement ‐ medium termAs defined in each study · psychosis‐induced aggression or agitation
It is very uncertain whether benzodiazepines plus antipsychotics changes global state: no improvement ‐ medium termAs defined in each study compared with antihistamines plus antipsychotics (very low certainty).
1 finding from 1 review
Global impression ‐ need for additional medication ‐ medium term Number of participants requiring additional medication · psychosis‐induced aggression or agitation
1 finding from 1 review
Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms · psychosis‐induced aggression or agitation
It is very uncertain whether benzodiazepines plus antipsychotics changes adverse effects/events: extrapyramidal symptoms ‐ medium termNumber… compared with antihistamines plus antipsychotics (very low certainty).
1 finding from 1 review
Satisfaction with treatment: from the perspective of consumer, family and informal carers or professionals/carers at any point during the acute management stage · psychosis‐induced aggression or agitation
1 finding from 1 review
Cost‐effectiveness · psychosis‐induced aggression or agitation
1 finding from 1 review
Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression
1 finding from 1 review
Depression severity (acute phase, 5 ≤ 12 weeks) · patients with major depression
1 finding from 1 review
Depression severity: continuous phase (> 12 weeks) · patients with major depression
1 finding from 1 review
Acceptability ‐ total dropouts · patients with major depression
Antidepressants plus benzodiazepines showed no clear difference in acceptability of treatment (dropout for any reason) compared with antidepressants alone (moderate certainty).
1 finding from 1 review
Anxiety · patients with major depression
1 finding from 1 review
Adverse effects (dropouts) · patients with major depression
Antidepressants plus benzodiazepines probably leads to lower adverse effects (dropouts) compared with antidepressants alone (moderate certainty).
1 finding from 1 review
Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with SAnD
Comparison 5: benzodiazepines may leads to higher global Impressions scale change item (CGI‐I or similar): no. of… compared with placebo (low certainty).
1 finding from 1 review
Relapse · adults with SAnD
Comparison 5: benzodiazepines showed no clear difference in relapse rate ‐ no. relapsed compared with placebo (low certainty).
1 finding from 1 review
Withdrawals due to adverse events · adults with SAnD
It is very uncertain whether comparison 5: benzodiazepines changes dropouts due to adverse events (acute phase) compared with placebo (very low certainty).
1 finding from 1 review
Reduction of of anxiety symptoms ‐ Clinician‐rated: LSAS total score · adults with SAnD
1 finding from 1 review
Reduction of of anxiety symptoms ‐ Clinician‐rated: LSAS avoidance subscale · adults with SAnD
1 finding from 1 review
Reduction of of anxiety symptoms ‐ Clinician‐rated: LSAS fear subscale · adults with SAnD
1 finding from 1 review
No clinically important response to treatment ‐ ultra short term (at 12 hours) · patients with schizophrenia
It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes no clinically important response to treatment ‐ ultra short term (at… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).
2 findings from 1 review
No clinically important response to treatment ‐ short term · patients with schizophrenia
It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes no clinically important response to treatment ‐ short term (3 weeks… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).
1 finding from 1 review