BENZODIAZEPINES + ANTIPSYCHOTICS vs ANTIHISTAMINES + ANTIPSYCHOTICS: Adverse effects/events ‐ extrapyramidal symptoms ‐ medium term Number of instances of extrapyramidal symptoms
It is very uncertain whether benzodiazepines plus antipsychotics changes adverse effects/events: extrapyramidal symptoms ‐ medium termNumber… compared with antihistamines plus antipsychotics (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Benzodiazepines plus antipsychotics vs antihistamines plus antipsychotics Adverse effects/events: extrapyramidal symptoms ‐ medium termNumber of instances of extrapyramidal symptoms · people with psychosis‐induced aggression or agitation It is very uncertain whether benzodiazepines plus antipsychotics changes adverse effects/events: extrapyramidal symptoms ‐ medium termNumber… compared with antihistamines plus antipsychotics (very low certainty). Benzodiazepines for psychosis‐induced aggression or agitation (2017) · Cochrane Headline outcomes only | RR 0.6 [0.16, 2.29] | 1 study · 60 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Benzodiazepines for psychosis‐induced aggression or agitation 2017 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.