Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

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707 questions · 750 findings · 36 reviews

No studies found 56 · 7.5%GRADE not reported 200 · 26.7%Very low 142 · 18.9%Low 186 · 24.8%Moderate 132 · 17.6%High 34 · 4.5%

Stand‐alone couple or family therapy vs other structured or non‐specific intervention

Dropout · post‐traumatic stress disorder (PTSD)

Stand‐alone couple or family therapy showed no clear difference in treatment dropout (treatment acceptability) compared with other structured or non‐specific intervention (low certainty).

1 finding from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment · management of opium withdrawal

It is very uncertain whether pharmacological detoxification treatment changes completion of treatment: baclofen versus clonidine compared with other pharmacological detoxification treatment (very low certainty).

4 findings from 1 review
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Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Withdrawal symptoms · management of opium withdrawal
4 findings from 1 review
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Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: clonidine versus clonidine plus amantadine, inpatient setting · management of opium withdrawal

It is very uncertain whether pharmacological detoxification treatment changes completion of treatment: clonidine versus clonidine plus amantadine,… compared with other pharmacological detoxification treatment (very low certainty).

1 finding from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: clonidine versus buprenorphine, inpatient setting · management of opium withdrawal

It is very uncertain whether pharmacological detoxification treatment changes completion of treatment: clonidine versus buprenorphine, inpatient… compared with other pharmacological detoxification treatment (very low certainty).

1 finding from 1 review

Pharmacological detoxification treatment vs other pharmacological detoxification treatment

Completion of treatment: methadone versus methadone plus gabapentin · management of opium withdrawal

Pharmacological detoxification treatment showed no clear difference in completion of treatment: methadone versus methadone plus gabapentin compared with other pharmacological detoxification treatment (low certainty).

1 finding from 1 review

Interferon‐α alone vs standard targeted therapies

QoL · previously untreated patients with mRCC
5 findings from 1 review
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