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What do systematic reviews say?

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Evidence found and GRADE certainty

20 questions · 20 findings · 2 reviews · Pregnancy and Childbirth

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No studies found 2 · 10%GRADE not reported 2 · 10%Very low 3 · 15%Low 9 · 45%Moderate 1 · 5%High 3 · 15%

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Probable early‐onset neonatal sepsis ‐ Early induction of labour · pregnant women with prelabour rupture of membranes at or near term

Any antibiotic showed no clear difference in probable early‐onset neonatal sepsis ‐ Early induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Probable early‐onset neonatal sepsis ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term

It is very uncertain whether any antibiotic changes probable early‐onset neonatal sepsis ‐ Late induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Definite early‐onset neonatal sepsis ‐ Early induction of labour · pregnant women with prelabour rupture of membranes at or near term

Any antibiotic showed no clear difference in definite early‐onset neonatal sepsis ‐ Early induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Definite early‐onset neonatal sepsis ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term

It is very uncertain whether any antibiotic changes definite early‐onset neonatal sepsis ‐ Late induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Early induction of labour · pregnant women with prelabour rupture of membranes at or near term

Any antibiotic showed no clear difference in maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no antibiotic

Maternal infectious morbidity (chorioamnionitis and/or endometritis) ‐ Late induction of labour · pregnant women with prelabour rupture of membranes at or near term

It is very uncertain whether any antibiotic changes maternal infectious morbidity (chorioamnionitis and/or endometritis)… compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (very low certainty).

1 finding from 1 review