Antibiotics vs placebo or no antibiotic: Definite early‐onset neonatal sepsis ‐ Early induction of labour
- Population
- pregnant women with prelabour rupture of membranes at or near term
- Intervention
- Antibiotics
- Comparison
- placebo or no antibiotic
- Outcome
- Definite early‐onset neonatal sepsis ‐ Early induction of labour
Any antibiotic showed no clear difference in definite early‐onset neonatal sepsis ‐ Early induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Any antibiotic vs placebo or no antibiotic (subgrouped by timing of induction of labour) Definite early‐onset neonatal sepsis ‐ Early induction of labour · pregnant women with prelabour rupture of membranes at or near term Any antibiotic showed no clear difference in definite early‐onset neonatal sepsis ‐ Early induction of labour compared with placebo or no antibiotic (subgrouped by timing of induction of labour) (low certainty). Antibiotics for prelabour rupture of membranes at or near term (2014) · Cochrane Headline outcomes only | RR 1.29 [0.48, 3.44] | 1 study · 1640 participants | Low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Antibiotics for prelabour rupture of membranes at or near term 2014 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.