Findings

What do systematic reviews say?

7 questions · 7 findings · 1 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 42.9%Low 4 · 57.1%Moderate 0 · 0%High 0 · 0%

Antihypertensive drug therapy vs control

All‐cause mortality · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy showed no clear difference in all‐cause mortality compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.94 [0.77, 1.13]
5 studies · 16776 participants
Low

Antihypertensive drug therapy vs control

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy may leads to lower total cardiovascular mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.78 [0.67, 0.91]
6 studies · 17278 participants
Low

Antihypertensive drug therapy vs control

Cerebrovascular mortality + morbidity · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy may leads to lower cerebrovascular mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.46 [0.34, 0.64]
6 studies · 17278 participants
Low

Antihypertensive drug therapy vs control

Coronary heart disease mortality + morbidity · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy showed no clear difference in coronary heart disease mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.99 [0.82, 1.19]
4 studies · 16241 participants
Low

Antihypertensive drug therapy vs control

Withdrawals due to adverse events · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

It is very uncertain whether antihypertensive drug therapy changes withdrawal due to adverse events compared with control (very low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 4.82 [1.67, 13.92]
3 studies · 1223 participants
Very low

Antihypertensive drug therapy vs control

Decrease in SBP5 at end of 1 year · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 14845 participants
Very low

Antihypertensive drug therapy vs control

Decrease in DBP6 at end of 1 year · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 15857 participants
Very low