Findings

What do systematic reviews say?

8 questions · 8 findings · 2 reviews

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 4 · 50%Moderate 3 · 37.5%High 1 · 12.5%

Any antihypertensive drug vs placebo or no treatment

Total mortality Mean duration of 3.8 years · adults 60 years or older with primary hypertension

Antihypertensive drug leads to lower total mortality Mean duration of 3.8 years compared with placebo or no treatment (high certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults 60 years or older 2019 · Cochrane Headline outcomes only
RR 0.91 [0.85, 0.97]
13 studies · 25932 participants
High

Any antihypertensive drug vs placebo or no treatment

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower cardiovascular mortality and morbidity Mean duration of 3.7 years compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults 60 years or older 2019 · Cochrane Headline outcomes only
RR 0.72 [0.68, 0.77]
15 studies · 26747 participants
Moderate

Any antihypertensive drug vs placebo or no treatment

Cerebrovascular mortality + morbidity · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower cerebrovascular mortality and morbidity Mean duration of 3.7 years compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults 60 years or older 2019 · Cochrane Headline outcomes only
RR 0.66 [0.59, 0.74]
13 studies · 26042 participants
Moderate

Any antihypertensive drug vs placebo or no treatment

Coronary heart disease mortality + morbidity · adults 60 years or older with primary hypertension

Antihypertensive drug probably leads to lower coronary heart disease mortality and morbidity Mean duration of 2.9… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults 60 years or older 2019 · Cochrane Headline outcomes only
RR 0.78 [0.69, 0.88]
11 studies · 24559 participants
Moderate

Antihypertensive drug therapy vs control

All‐cause mortality · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy showed no clear difference in all‐cause mortality compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.94 [0.77, 1.13]
5 studies · 16776 participants
Low

Antihypertensive drug therapy vs control

Cerebrovascular mortality + morbidity · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy may leads to lower cerebrovascular mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.46 [0.34, 0.64]
6 studies · 17278 participants
Low

Antihypertensive drug therapy vs control

Cardiovascular mortality and morbidity Mean duration of 3.7 years · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy may leads to lower total cardiovascular mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.78 [0.67, 0.91]
6 studies · 17278 participants
Low

Antihypertensive drug therapy vs control

Coronary heart disease mortality + morbidity · adults aged 18‐59 years with primary hypertension (mild to moderate systolic or diastolic hypertension)

Antihypertensive drug therapy showed no clear difference in coronary heart disease mortality + morbidity compared with control (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults aged 18 to 59 years 2017 · Cochrane Headline outcomes only
RR 0.99 [0.82, 1.19]
4 studies · 16241 participants
Low