Findings

What do systematic reviews say?

11 questions · 12 findings · 2 reviews · Common Mental Disorders

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 25%Low 5 · 41.7%Moderate 4 · 33.3%High 0 · 0%

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity ‐ mean EPDS score (early phase, < 5 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 598 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity (acute phase, 5 ≤ 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 347 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Depression severity: continuous phase (> 12 weeks) · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 50 participants
Low

Antidepressants plus benzodiazepines vs antidepressants alone

Acceptability ‐ total dropouts · patients with major depression

Antidepressants plus benzodiazepines showed no clear difference in acceptability of treatment (dropout for any reason) compared with antidepressants alone (moderate certainty).

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
RR 0.76 [0.54, 1.07]
10 studies · 731 participants
Moderate

Antidepressants plus benzodiazepines vs antidepressants alone

Anxiety · patients with major depression

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 129 participants
Very low

Antidepressants plus benzodiazepines vs antidepressants alone

Adverse effects (dropouts) · patients with major depression

Antidepressants plus benzodiazepines probably leads to lower adverse effects (dropouts) compared with antidepressants alone (moderate certainty).

1 finding from 1 review

Antidepressants plus benzodiazepines for adults with major depression 2019 · Cochrane Headline outcomes only
RR 0.54 [0.32, 0.9]
10 studies · 731 participants
Moderate

Antidepressants vs benzodiazepines

Failure to respond at endpoint (6‐12 weeks) · adults with panic disorder

Antidepressants showed no clear difference in failure to respond compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 0.99 [0.67, 1.47]
2 studies · 215 participants
Low

Antidepressants vs benzodiazepines

Leaving the study early · adults with panic disorder

It is very uncertain whether antidepressants changes total number of dropouts compared with benzodiazepines (very low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.64 [1.03, 2.63]
7 studies · 1449 participants
Very low

Antidepressants vs benzodiazepines

Failure to remit at endpoint · adults with panic disorder

Antidepressants probably leads to higher failure to remit compared with benzodiazepines (moderate certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.18 [1.01, 1.37]
3 studies · 1002 participants
Moderate

Antidepressants vs benzodiazepines

panic symptoms · adults with panic disorder

2 findings from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 1144 participants
Very low
Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 44 participants
Low

Antidepressants vs benzodiazepines

Withdrawals due to adverse events · adults with panic disorder

Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

1 finding from 1 review

Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
RR 1.72 [1.03, 2.87]
3 studies · 1002 participants
Low