Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

204 questions · 212 findings · 23 reviews

No studies found 49 · 23.1%GRADE not reported 3 · 1.4%Very low 70 · 33%Low 63 · 29.7%Moderate 25 · 11.8%High 2 · 0.9%

Antidepressants vs placebo

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes adverse events: death ‐ at end of treatment Analysis 1.12 compared with placebo (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs another medication

Treatment response (post‐treatment score on self report and clinician‐rated scales) · somatoform disorders in adults

Tricyclic antidepressants showed no clear difference in treatment response (post‐treatment score on self report and… compared with another medication (low certainty).

1 finding from 1 review