Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

120 questions · 126 findings · 18 reviews

No studies found 14 · 11.1%GRADE not reported 3 · 2.4%Very low 40 · 31.7%Low 47 · 37.3%Moderate 20 · 15.9%High 2 · 1.6%

Antidepressants vs placebo: all studies

Response to antidepressive treatment · people with co‐occurring depression and alcohol dependence

It is very uncertain whether antidepressants changes response to antidepressive treatment compared with placebo: all studies (very low certainty).

1 finding from 1 review

Antidepressants vs placebo: all studies

Consumption of alcohol: abstinent participants (number) · people with co‐occurring depression and alcohol dependence

Antidepressants probably leads to higher consumption of alcohol: abstinent participants (number) compared with placebo: all studies (moderate certainty).

1 finding from 1 review

Antidepressants vs placebo: all studies

Tolerability of treatment: withdrawal for medical reasons · people with co‐occurring depression and alcohol dependence

Antidepressants showed no clear difference in tolerability of treatment: withdrawal for medical reasons compared with placebo: all studies (low certainty).

1 finding from 1 review

Antidepressants vs placebo according to any definition

Dropout ‐ Dropouts: excluding studies with high risk of bias objective · patients with cocaine abuse and dependence

Antidepressants showed no clear difference in dropout ‐ Dropouts: excluding studies with high risk of bias objective compared with placebo according to any definition (moderate certainty).

1 finding from 1 review