Antidepressants vs placebo
Adverse events · women of any age, with PND up to 12 months
Antidepressants may leads to lower adverse events compared with placebo (low certainty).
1 finding from 1 review
- no estimate extractedStudies not reportedLow
Findings
What do systematic reviews say?
9 questions · 9 findings · 7 reviews
No studies found 1 · 11.1%GRADE not reported 0 · 0%Very low 1 · 11.1%Low 4 · 44.4%Moderate 3 · 33.3%High 0 · 0%
'Other' antidepressants vs placebo
Adverse events · adults with insomnia
1 finding from 1 review
- no estimate extracted2 studies · 217 participantsLow
Antidepressants vs placebo
Adverse events at 12 months · people with inflammatory bowel disease
Antidepressants showed no clear difference in adverse events at 12 months compared with placebo (low certainty).
1 finding from 1 review
- Adjuvant therapy with antidepressants for the management of inflammatory bowel disease 2019 · Cochrane Headline outcomes onlyRR 2.29 [0.78, 6.73]1 study · 26 participantsLow
Antidepressants vs placebo
Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo (moderate certainty).
1 finding from 1 review
- Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes onlyRR 3.03 [1.2, 7.68]3 studies · 276 participantsModerate
Antidepressants vs placebo according to any definition
Adverse events ‐ Withdrawn for medical reasons · patients with depression during opioid agonist treatment for opioid dependence
Antidepressants probably leads to higher adverse events ‐ Withdrawn for medical reasons compared with placebo according to any definition (moderate certainty).
1 finding from 1 review
- Pharmacological treatment for depression during opioid agonist treatment for opioid dependence 2010 · Cochrane Headline outcomes onlyRR 2.9 [1.23, 6.86]4 studies · 311 participantsModerate
Antidepressants vs placebo according to any definition
Number withdrawn due to adverse events · patients with cocaine abuse and dependence
Antidepressants showed no clear difference in adverse events ‐ Withdrawn due to adverse events compared with placebo according to any definition (moderate certainty).
1 finding from 1 review
- Antidepressants for cocaine dependence and problematic cocaine use 2011 · Cochrane Headline outcomes onlyRR 1.39 [0.91, 2.12]13 studies · 1396 participantsModerate
Antidepressants vs placebo
Non‐serious adverse events Timing of outcome assessment: end of treatment · patients with borderline personality disorder
The review found no eligible studies for this question.
1 finding from 1 review
- Pharmacological interventions for people with borderline personality disorder 2022 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found
Tricyclic antidepressants vs placebo
Adverse events (at 4, 6 or 12 weeks) · adults with insomnia
Tricyclic antidepressants showed no clear difference in adverse events (at 4, 6 or 12 weeks) compared with placebo (low certainty).
1 finding from 1 review
- RR 1.02 [0.86, 1.21]6 studies · 812 participantsLow
Antidepressants vs placebo
Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke
It is very uncertain whether pharmacological interventions (antidepressants) changes adverse events: death ‐ at end of treatment Analysis 1.12 compared with placebo (very low certainty).
1 finding from 1 review
- Pharmacological, psychological and non‐invasive brain stimulation interventions for preventing depression after stroke 2020 · Cochrane Headline outcomes onlyRR 1.25 [0.32, 4.91]9 studies · 496 participantsVery low