Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

349 questions · 364 findings · 37 reviews

No studies found 96 · 26.4%GRADE not reported 8 · 2.2%Very low 105 · 28.8%Low 94 · 25.8%Moderate 46 · 12.6%High 15 · 4.1%

Antidepressants vs placebo

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether pharmacological interventions (antidepressants) changes adverse events: death ‐ at end of treatment Analysis 1.12 compared with placebo (very low certainty).

1 finding from 1 review

Tricyclic antidepressants vs placebo

Benzodiazepine discontinuation, end of intervention · adults who withdraw from chronic benzodiazepine use

It is very uncertain whether tricyclic antidepressants changes benzodiazepine discontinuation, end of intervention compared with placebo (very low certainty).

1 finding from 1 review