What do systematic reviews say?

Antidepressants vs placebo

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  15 studies · 3699 participants
  Low
• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 2010 participants
  Low

Antidepressants vs placebo

Antidepressants probably leads to higher number of dropouts due to adverse effects compared with placebo (moderate certainty).

• Antidepressants versus placebo for panic disorder in adults 2018 · Cochrane Headline outcomes only
  RR 1.49 [1.25, 1.78]
  33 studies · 7688 participants
  Moderate

Antidepressants vs benzodiazepines

Antidepressants showed no clear difference in failure to respond compared with benzodiazepines (low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 0.99 [0.67, 1.47]
  2 studies · 215 participants
  Low

Antidepressants vs benzodiazepines

It is very uncertain whether antidepressants changes total number of dropouts compared with benzodiazepines (very low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.64 [1.03, 2.63]
  7 studies · 1449 participants
  Very low

Antidepressants vs benzodiazepines

Antidepressants probably leads to higher failure to remit compared with benzodiazepines (moderate certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.18 [1.01, 1.37]
  3 studies · 1002 participants
  Moderate

Antidepressants vs benzodiazepines

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 1144 participants
  Very low
• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 44 participants
  Low

Antidepressants vs benzodiazepines

Antidepressants may leads to higher number of dropouts due to adverse effects compared with benzodiazepines (low certainty).

• Antidepressants and benzodiazepines for panic disorder in adults 2016 · Cochrane Headline outcomes only
  RR 1.72 [1.03, 2.87]
  3 studies · 1002 participants
  Low

Antidepressants vs placebo according to any definition

Antidepressants showed no clear difference in dropout ‐ Dropouts: excluding studies with high risk of bias objective compared with placebo according to any definition (moderate certainty).

• Antidepressants for cocaine dependence and problematic cocaine use 2011 · Cochrane Headline outcomes only
  RR 1.01 [0.91, 1.12]
  27 studies · 2417 participants
  Moderate

Antidepressants vs placebo according to any definition

Antidepressants showed no clear difference in abstinence, for at least three consecutive weeks objective compared with placebo according to any definition (high certainty).

• Antidepressants for cocaine dependence and problematic cocaine use 2011 · Cochrane Headline outcomes only
  RR 1.22 [0.99, 1.51]
  8 studies · 942 participants
  High

Antidepressants vs placebo according to any definition

Antidepressants showed no clear difference in adverse events ‐ Withdrawn due to adverse events compared with placebo according to any definition (moderate certainty).

• Antidepressants for cocaine dependence and problematic cocaine use 2011 · Cochrane Headline outcomes only
  RR 1.39 [0.91, 2.12]
  13 studies · 1396 participants
  Moderate

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 146 participants
  Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 104 participants
  Low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 146 participants
  Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

The review found no eligible studies for this question.

• Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SSRI antidepressants vs tricyclic antidepressants (TCAs)

The review found no eligible studies for this question.

• Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

SSRI antidepressants vs tricyclic antidepressants (TCAs)

It is very uncertain whether SSRI antidepressants changes drop‐outs (12 weeks) compared with TCA (very low certainty).

• Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
  RR 0.34 [0.11, 1.01]
  1 study · 25 participants
  Very low

SSRI antidepressants vs tricyclic antidepressants (TCAs)

• Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 141 participants
  Moderate

SSRI antidepressants vs tricyclic antidepressants (TCAs)

• Interventions for preventing type 2 diabetes in adults with mental disorders in low‐ and middle‐income countries 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low