Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes hearing ‐ return to normal hearing (as complete improvement in… compared with placebo (very low certainty).
1 finding from 1 review
Disease‐specific quality of life · children aged 6 months to 12 years with otitis media with effusion (OME)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes presence/persistence of OME compared with placebo (very low certainty).
1 finding from 1 review
RR 0.89 [0.68, 1.17]
Studies not reported
Very low
Adverse event: anaphylaxis · children aged 6 months to 12 years with otitis media with effusion (OME)
It is very uncertain whether antibiotics changes adverse event: anaphylaxis compared with placebo (very low certainty).
1 finding from 1 review
no estimate extracted
Studies not reported
Very low
Complete resolution of OME at 2 to 3 months · Children with otitis media with effusion
Antibiotics probably leads to higher complete resolution of OME at 2 to 3 months compared with placebo, no treatment or therapy of unproven effectiveness (moderate certainty).
2 findings from 1 review
Adverse effects · Children with otitis media with effusion
Antibiotics may leads to higher adverse effects compared with placebo, no treatment or therapy of unproven effectiveness (low certainty).
1 finding from 1 review
Complete resolution of OME at more than 6 months · Children with otitis media with effusion
Antibiotics may leads to higher complete resolution of OME at more than 6 months compared with placebo, no treatment or therapy of unproven effectiveness (low certainty).
1 finding from 1 review
Insertion of ventilation tubes · Children with otitis media with effusion
Antibiotics showed no clear difference in insertion of ventilation tubes compared with placebo, no treatment or therapy of unproven effectiveness (low certainty).
1 finding from 1 review
Tympanic membrane sequelae · Children with otitis media with effusion
Antibiotics showed no clear difference in tympanic membrane sequelae compared with placebo, no treatment or therapy of unproven effectiveness (low certainty).
1 finding from 1 review
Resolution of ear discharge ‐ measured at 1 to 2 weeks · patients with mucopurulent otorrhoea
It is very uncertain whether topical antibiotics changes resolution of ear discharge ‐ measured at 1 to 2 weeks compared with placebo/no treatment (very low certainty).
1 finding from 1 review
Resolution of ear discharge ‐ measured after 4 weeks · patients with mucopurulent otorrhoea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Health‐related quality of life · patients with mucopurulent otorrhoea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ear pain (otalgia) or discomfort or local irritation · patients with mucopurulent otorrhoea
1 finding from 1 review
Hearing · patients with mucopurulent otorrhoea
1 finding from 1 review
Serious complications · patients with mucopurulent otorrhoea
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Suspected ototoxicity · patients with mucopurulent otorrhoea
1 finding from 1 review
Resolution of ear discharge ‐ measured at 1 to 2 weeks · children with CSOM
It is very uncertain whether systemic antibiotics changes resolution of ear discharge ‐ measured at 1 to 2 weeks compared with no treatment/placebo (very low certainty).
1 finding from 1 review
Health‐related quality of life · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Ear pain (otalgia) or discomfort or local irritation · people (of any age) with CSOM
It is very uncertain whether systemic antibiotics changes ear pain (otalgia) or discomfort or local irritation ‐ measured at 1… compared with no treatment or placebo on top of topical antibiotics (very low certainty).
1 finding from 1 review
Hearing · people (of any age) with CSOM
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found