Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

98 questions · 103 findings · 14 reviews · Headline outcomes only

No studies found 50 · 48.5%GRADE not reported 0 · 0%Very low 21 · 20.4%Low 15 · 14.6%Moderate 9 · 8.7%High 8 · 7.8%

Oral antibiotics vs placebo

Economic costs and benefits of different interventions · adult participants with chronic blepharitis

The review found no eligible studies for this question.

1 finding from 1 review

Antibiotics vs placebo or no intervention

Cardiovascular mortality · patients with coronary heart disease

Antibiotics leads to higher cardiovascular mortality at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Myocardial infarction · patients with coronary heart disease

Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Stroke · patients with coronary heart disease

Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo

Death at 6 months · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in death at 6 months compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Remission · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in remission at one year compared with placebo (low certainty).

1 finding from 1 review