Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 28 findings · 2 reviews

No studies found 5 · 17.9%GRADE not reported 8 · 28.6%Very low 7 · 25%Low 4 · 14.3%Moderate 1 · 3.6%High 3 · 10.7%

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Antibiotics vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to maintain clinical remission at end of study · Patients with quiescent ulcerative colitis

It is very uncertain whether antibiotics changes failure to maintain clinical remission at end of study compared with 5‐ASA (very low certainty).

1 finding from 1 review