Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

594 questions · 624 findings · 70 reviews

No studies found 151 · 24.2%GRADE not reported 53 · 8.5%Very low 174 · 27.9%Low 129 · 20.7%Moderate 82 · 13.1%High 35 · 5.6%

Antibiotics vs placebo or no intervention

Stroke · patients with coronary heart disease

Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo or usual care

Serious adverse events Duration 3 days to 3 weeks · acute asthma exacerbation

Antibiotics showed no clear difference in serious adverse events Duration 3 days to 3 weeks compared with placebo or usual care (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Children not cured or substantially improved at · prolonged wet cough in children

Antibiotics probably leads to lower children not cured or substantially improved at compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Children with progression of the disease resulting in additional medical therapy (complications) (measured as proportion of participants) · prolonged wet cough in children

Antibiotics probably leads to lower children with progression of the disease resulting in additional… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Cure in adults with clinically diagnosed acute rhinosinusitis · acute rhinosinusitis in adults, whether clinically diagnosed or confirmed by imaging

Antibiotics leads to higher cure in adults with clinically diagnosed acute rhinosinusitis compared with placebo (high certainty).

1 finding from 1 review