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What do systematic reviews say?

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Evidence found and GRADE certainty

82 questions · 83 findings · 8 reviews · Pregnancy and Childbirth

No studies found 16 · 19.3%GRADE not reported 19 · 22.9%Very low 10 · 12%Low 20 · 24.1%Moderate 10 · 12%High 8 · 9.6%

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (superficial perineal wound infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (superficial perineal wound… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (deep perineal wound infection № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics leads to lower infected episiotomy/laceration (deep perineal wound infection № of… compared with placebo or no treatment (high certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (organ or space infection) № of participants: 3420 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics showed no clear difference in infected episiotomy/laceration (organ or space infection) № of… compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Infected episiotomy/laceration (wound breakdown) № of participants: 2593 (1 RCT) · Women undergoing operative vaginal delivery

Any antibiotics probably leads to lower infected episiotomy/laceration (wound breakdown) № of participants:… compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo

Preterm prelabour rupture of membranes · women in the second or third trimester of pregnancy before labour and delivery

Prophylactic antibiotics showed no clear difference in preterm prelabour rupture of membranes compared with placebo (low certainty).

1 finding from 1 review