Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

594 questions · 624 findings · 70 reviews

No studies found 151 · 24.2%GRADE not reported 53 · 8.5%Very low 174 · 27.9%Low 129 · 20.7%Moderate 82 · 13.1%High 35 · 5.6%

Summary of findings: Inhaled antibiotics vs IV antibiotics

Need for additional IV or oral antibiotics · adults and children with cystic fibrosis (during acute exacerbations of lung disease)

It is very uncertain whether summary of findings: Inhaled antibiotics changes need for additional IV or oral antibiotics compared with IV antibiotics (very low certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 24 hours · children with acute otitis media

Antibiotics showed no clear difference in pain ‐ pain at 24 hours compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 2 to 3 days · children with acute otitis media

Antibiotics leads to lower pain ‐ pain at 2 to 3 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 4 to 7 days · children with acute otitis media

Antibiotics showed no clear difference in pain ‐ pain at 4 to 7 days compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Pain ‐ pain at 10 to 12 days · children with acute otitis media

Antibiotics probably leads to lower pain ‐ pain at 10 to 12 days compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Vomiting, diarrhoea or rash · children with acute otitis media

Antibiotics leads to higher vomiting, diarrhoea or rash compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Abnormal tympanometry ‐ 2 to 4 weeks · children with acute otitis media

Antibiotics leads to lower abnormal tympanometry ‐ 2 to 4 weeks compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Abnormal tympanometry ‐ 3 months · children with acute otitis media

Antibiotics showed no clear difference in abnormal tympanometry ‐ 3 months compared with placebo (high certainty).

1 finding from 1 review

Antibiotics vs placebo

Treatment incompletion (RR < 1 favored) · Participants with acute bacterial conjunctivitis

Antibiotics probably leads to lower treatment incompletion (RR < 1 favored) compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Persistent clinical infection after one course of treatment (RR < 1 favored) · Participants with acute bacterial conjunctivitis

Antibiotics probably leads to lower persistent clinical infection after one course of treatment (RR < 1… compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Treatment‐associated ocular complications (RR < 1 or RD ≤ 0 favored) · Participants with acute bacterial conjunctivitis

It is very uncertain whether antibiotics changes treatment‐associated ocular complications (RR < 1 or RD ≤ 0 favored) compared with placebo (very low certainty).

1 finding from 1 review