Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

594 questions · 624 findings · 70 reviews

No studies found 151 · 24.2%GRADE not reported 53 · 8.5%Very low 174 · 27.9%Low 129 · 20.7%Moderate 82 · 13.1%High 35 · 5.6%

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Stenosis or thrombosis of vascular access site after catheter removal · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Prophylactic antibiotics vs placebo or no treatment

Surgical site infection · women with urinary stress incontinence undergoing continence surgery

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of surgical site infections (SSIs) before discharge compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo or no treatment

Number of symptomatic UTIs or bacteriuria before discharge · women with urinary stress incontinence undergoing continence surgery

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of symptomatic UTIs or bacteriuria before discharge compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo or no treatment

Febrile morbidity · women with urinary stress incontinence undergoing continence surgery

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of women with febrile morbidity at hospital discharge compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Prophylactic antibiotics vs placebo or no treatment

Mesh exposure · women with urinary stress incontinence undergoing continence surgery

It is very uncertain whether prophylactic antibiotics (single or combined drugs) changes number of mesh exposures within six weeks after the operation compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ first dose and referral · neonates with sepsis

Comparison 1: referral or full course of antibiotics may leads to lower neonatal mortality ‐ first dose and referral compared with standard care (low certainty).

1 finding from 1 review

Comparison 1: referral or full course of antibiotics vs usual care

Neonatal mortality ‐ full course · neonates with sepsis

It is very uncertain whether comparison 1: referral or full course of antibiotics changes neonatal mortality ‐ full course compared with standard care (very low certainty).

1 finding from 1 review

Treatment failure with anti‐gram‐positive antibiotics vs placebo

Overall failure (disregarding modifications) · people with cancer who have febrile neutropenia

Treatment failure with anti‐gram‐positive antibiotics showed no clear difference in overall failure (disregarding modifications) compared with placebo (low certainty).

1 finding from 1 review

Treatment failure with anti‐gram‐positive antibiotics vs placebo

Failure, modifications included · people with cancer who have febrile neutropenia

It is very uncertain whether treatment failure with anti‐gram‐positive antibiotics changes failure, modifications included compared with placebo (very low certainty).

1 finding from 1 review

Gastrointestinal adverse events in people taking macrolide antibiotics vs placebo

Gastrointestinal disorders not otherwise specified · any indication

Gastrointestinal adverse events in people taking macrolide antibiotics probably leads to higher gastrointestinal disorders not otherwise specified compared with placebo (moderate certainty).

1 finding from 1 review