Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

294 questions · 308 findings · 41 reviews

No studies found 65 · 21.1%GRADE not reported 21 · 6.8%Very low 83 · 26.9%Low 66 · 21.4%Moderate 47 · 15.3%High 26 · 8.4%

Antibiotics vs placebo or no intervention

Cardiovascular mortality · patients with coronary heart disease

Antibiotics leads to higher cardiovascular mortality at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Myocardial infarction · patients with coronary heart disease

Antibiotics showed no clear difference in myocardial infarction at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Stroke · patients with coronary heart disease

Antibiotics showed no clear difference in stroke at 24±6 months compared with placebo or no intervention (high certainty).

2 findings from 1 review

Antibiotics vs placebo or no intervention

Sudden cardiac death · patients with coronary heart disease

Antibiotics probably leads to higher sudden cardiac death at 24±6 months compared with placebo or no intervention (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo

Death at 6 months · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in death at 6 months compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Remission · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in remission at one year compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Discontinuation of medication due to adverse events · adults with renal vasculitis for maintenance therapy

Antibiotics showed no clear difference in adverse events causing study drug discontinuation compared with placebo (low certainty).

1 finding from 1 review

Antibiotics vs placebo

Urinary tract infection · adults with renal vasculitis for maintenance therapy

Antibiotics may leads to lower infection (urinary tract infection) compared with placebo (low certainty).

1 finding from 1 review