Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

711 questions · 751 findings · 86 reviews

No studies found 171 · 22.8%GRADE not reported 61 · 8.1%Very low 192 · 25.6%Low 174 · 23.2%Moderate 108 · 14.4%High 45 · 6%

Antibiotics vs placebo or no treatment

Number of participants who were not cured at · children < 24 months with ongoing symptoms (cough/wheeze) post‐acute bronchiolitis

Antibiotics showed no clear difference in number of participants who were not cured at compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Number of participants rehospitalised for a respiratory illness · children < 24 months with ongoing symptoms (cough/wheeze) post‐acute bronchiolitis

Antibiotics showed no clear difference in number of participants rehospitalised for a respiratory illness compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no treatment

Proportion of participants with recurrent wheeze · children < 24 months with ongoing symptoms (cough/wheeze) post‐acute bronchiolitis

Antibiotics showed no clear difference in proportion of participants with recurrent wheeze compared with placebo or no treatment (low certainty).

1 finding from 1 review

Antibiotics vs placebo, no treatment or therapy of unproven effectiveness

Complete resolution of OME at 2 to 3 months · Children with otitis media with effusion

Antibiotics probably leads to higher complete resolution of OME at 2 to 3 months compared with placebo, no treatment or therapy of unproven effectiveness (moderate certainty).

2 findings from 1 review

Antibiotics vs placebo, no treatment or therapy of unproven effectiveness

Complete resolution of OME at more than 6 months · Children with otitis media with effusion

Antibiotics may leads to higher complete resolution of OME at more than 6 months compared with placebo, no treatment or therapy of unproven effectiveness (low certainty).

1 finding from 1 review