Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

711 questions · 751 findings · 86 reviews

No studies found 171 · 22.8%GRADE not reported 61 · 8.1%Very low 192 · 25.6%Low 174 · 23.2%Moderate 108 · 14.4%High 45 · 6%

Antibiotics vs placebo

Exacerbations · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics probably leads to lower number of people with one or more exacerbations WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Annual Exacerbation Rates · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics probably leads to lower rate of exacerbation per patient/year WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

All‐cause mortality WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in all‐cause mortality WMD of compared with placebo (moderate certainty).

1 finding from 1 review

Antibiotics vs placebo

Serious adverse events WMD of · Adults (aged 40 or over) with COPD presenting with 1 or more exacerbations in the previous year. The 2 larger studies (Albert 2011; Sethi…

Antibiotics showed no clear difference in serious adverse events WMD of compared with placebo (moderate certainty).

1 finding from 1 review