Findings

What do systematic reviews say?

9 questions · 12 findings · 2 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 41.7%Moderate 6 · 50%High 1 · 8.3%

Survival to hospital discharge · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in survival to hospital discharge compared with placebo (moderate certainty).

2 findings from 1 review

Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only
OR 0.58 [0.12, 2.74]
5 studies · 1254 participants
Moderate
Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 37 participants
Low

Return of spontaneous circulation · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in return of spontaneous circulation compared with placebo (high certainty).

2 findings from 1 review

Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only
OR 1.15 [0.89, 1.49]
5 studies · 1254 participants
High
Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only
OR 1.61 [0.38, 6.77]
2 studies · 37 participants
Low

Early administration of aminophylline: survival to hospital admission · participants with bradyasystolic cardiac arrest in adults

Aminophylline showed no clear difference in survival to admission compared with placebo (moderate certainty).

2 findings from 1 review

Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only
OR 0.92 [0.61, 1.39]
4 studies · 1232 participants
Moderate
Aminophylline for bradyasystolic cardiac arrest in adults 2015 · Cochrane Headline outcomes only
OR 0.22 [0.02, 2.36]
2 studies · 37 participants
Low

PEF (L/min) · patients with adults with acute asthma

Aminophylline showed no clear difference in PEF (L/min) ‐ at 60 min compared with placebo (low certainty).

1 finding from 1 review

Hospital admissions · patients with adults with acute asthma

Aminophylline showed no clear difference in hospital admissions compared with placebo (moderate certainty).

1 finding from 1 review

Addition of intravenous aminophylline to inhaled beta₂‐agonists in adults with acute asthma 2012 · Cochrane Headline outcomes only
OR 0.58 [0.3, 1.12]
6 studies · 315 participants
Moderate

Tremor · patients with adults with acute asthma

Aminophylline showed no clear difference in tremor compared with placebo (low certainty).

1 finding from 1 review

Vomiting · patients with adults with acute asthma

Aminophylline probably leads to higher vomiting compared with placebo (moderate certainty).

1 finding from 1 review

Addition of intravenous aminophylline to inhaled beta₂‐agonists in adults with acute asthma 2012 · Cochrane Headline outcomes only
OR 4.21 [2.2, 8.07]
7 studies · 321 participants
Moderate

Arrhythmia/palpitations · patients with adults with acute asthma

Aminophylline probably leads to higher arrhythmia/palpitations compared with placebo (moderate certainty).

1 finding from 1 review

Addition of intravenous aminophylline to inhaled beta₂‐agonists in adults with acute asthma 2012 · Cochrane Headline outcomes only
OR 3.02 [1.15, 7.9]
6 studies · 249 participants
Moderate

Convulsions · patients with adults with acute asthma

1 finding from 1 review

Addition of intravenous aminophylline to inhaled beta₂‐agonists in adults with acute asthma 2012 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Moderate