Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

8 questions · 10 findings · 3 reviews

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 10%Low 5 · 50%Moderate 2 · 20%High 2 · 20%

Adjunctive steroid vs placebo

Hearing loss · neonates with clinical and microbiological features of bacterial meningitis

Adjunctive steroid showed no clear difference in hearing loss at 2 years of age compared with placebo (low certainty).

2 findings from 1 review

Adjunctive corticosteroids vs no such treatment

Need for mechanical ventilation · patients with Pneumocystis jiroveci pneumonia and HIV infection

Adjunctive corticosteroids probably leads to lower need for mechanical ventilation at 1 month compared with no such treatment (moderate certainty).

1 finding from 1 review

Intralesional steroid injection plus adjunctive treatment vs steroid injection

Maximal mouth opening (interincisal distance) · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Intralesional steroid injection plus adjunctive treatment showed no clear difference in maximal mouth opening (interincisal distance) compared with intralesional steroid injection alone (low certainty).

2 findings from 1 review