Gap finder

Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

601 questions in 75 reviews · Schizophrenia

current versions
No studies 601 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Motivational interview plus oral health education vs Oral health education
Adverse events: Clinically important specific adverse events · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
No study reported useable data0 studiesNo studies
Oral health education (advice and training) vs Standard care (oral health advice not specifically emphasised beyond usual care)
Oral health: Not having seen a dentist in the past year · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
No study reported useable data0 studiesNo studies
Oral health education (advice and training) vs Standard care (oral health advice not specifically emphasised beyond usual care)
Economic: Increased costs of health care · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
no estimate extracted0 studiesNo studies
Motivational interview plus oral health education vs Oral health education
Service use: Emergency medical/dental treatment · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
No study reported useable data0 studiesNo studies
RISPERIDONE DEPOT vs PLACEBO
Global state: Relapse ‐ long term ‐ not measured · patients with schizophrenia
Risperidone (depot) for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
RISPERIDONE DEPOT vs PLACEBO
Mental state: clinically significant improvement in mental state ‐ long term1 ‐ not reported · patients with schizophrenia
Risperidone (depot) for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
RISPERIDONE DEPOT vs TYPICAL DEPOT ANTIPSYCHOTICS
Adverse events: related to movement disorder, weight gain, prolactin levels and glucose metabolism ‐ medium/long term ‐ not reported · patients with schizophrenia
Risperidone (depot) for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
RISPERIDONE + CLOZAPINE vs PLACEBO + CLOZAPINE
Adverse effects: extrapyramidal ‐ short term · people with schizophrenia
Risperidone versus placebo for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Improvement in nutritional intake · participants with schizophrenia
Dietary advice for people with schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Change in measures of nutritional status: weight (kg), body mass index (kg/ m2), and waist/ hip ratio (cms) · participants with schizophrenia
Dietary advice for people with schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Mental state · participants with schizophrenia
Dietary advice for people with schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Clinically important adverse effects · participants with schizophrenia
Dietary advice for people with schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Measures of physiological function · participants with schizophrenia
Dietary advice for people with schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Smoking cessation advice vs standard care
Raised awareness of common problems associated with smoking · people with people with serious mental illness
Smoking cessation advice for people with serious mental illness (2016) · Cochrane
no estimate extractedNRNo studies
Smoking cessation advice vs standard care
Reduction in smoking · people with people with serious mental illness
Smoking cessation advice for people with serious mental illness (2016) · Cochrane
no estimate extractedNRNo studies
Smoking cessation advice vs standard care
Healthy days · people with people with serious mental illness
Smoking cessation advice for people with serious mental illness (2016) · Cochrane
no estimate extractedNRNo studies
Smoking cessation advice vs standard care
Clinically important adverse effect · people with people with serious mental illness
Smoking cessation advice for people with serious mental illness (2016) · Cochrane
no estimate extractedNRNo studies
Smoking cessation advice vs standard care
Economic outcome · people with people with serious mental illness
Smoking cessation advice for people with serious mental illness (2016) · Cochrane
no estimate extractedNRNo studies
HALOPERIDOL vs OTHER ANTIPSYCHOTICS
Specific behaviour: repeated need for tranquillisation · people with long‐term aggression in psychosis
Haloperidol for long‐term aggression in psychosis (2016) · Cochrane
no estimate extractedNRNo studies
HALOPERIDOL vs OTHER ANTIPSYCHOTICS
Adverse effects ‐ any serious, specific adverse effects · people with long‐term aggression in psychosis
Haloperidol for long‐term aggression in psychosis (2016) · Cochrane
no estimate extractedNRNo studies
HALOPERIDOL vs OTHER ANTIPSYCHOTICS
Economic outcomes · people with long‐term aggression in psychosis
Haloperidol for long‐term aggression in psychosis (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs RISPERIDONE
Clinically important change in life skills (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs RISPERIDONE
Quality of life (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs RISPERIDONE
Adverse effects: Extrapyramidal effects ‐ short/medium term (up to 12 weeks) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs RISPERIDONE
Cost‐effectiveness (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs QUETIAPINE
Relapse (long term) · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs QUETIAPINE
Clinically important change in life skills (long term) · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs QUETIAPINE
Quality of life (long term) · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs QUETIAPINE
Adverse effects: Extrapyramidal effects ‐ short/medium term (up to 12 weeks) · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs AMISULPRIDE
Relapse (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs QUETIAPINE
Cost‐effectiveness (long term) · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs OLANZAPINE
Relapse (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs OLANZAPINE
Clinically important change in life skills (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs OLANZAPINE
Quality of life (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs OLANZAPINE
Cost‐effectiveness (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs AMISULPRIDE
Clinically important change in life skills (long term) ‐ not measured · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs AMISULPRIDE
Quality of life (long term) ‐ not measured · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs AMISULPRIDE
Cost‐effectiveness (long term) ‐ not measured · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE (ORAL) vs RISPERIDONE
Relapse (long term) ‐ not reported · patients with schizophrenia
Fluphenazine (oral) versus atypical antipsychotics for schizophrenia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Clinical improvement in pulse rate · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia
Pharmacological interventions for clozapine‐induced sinus tachycardia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Improvement in heart rate · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia
Pharmacological interventions for clozapine‐induced sinus tachycardia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Duration of hospitalisation · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia
Pharmacological interventions for clozapine‐induced sinus tachycardia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Clinically important adverse events · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia
Pharmacological interventions for clozapine‐induced sinus tachycardia (2016) · Cochrane
no estimate extractedNRNo studies
Intervention NR
Patient satisfaction · adults with schizophrenia or related disorders treated for clozapine‐induced tachycardia
Pharmacological interventions for clozapine‐induced sinus tachycardia (2016) · Cochrane
no estimate extractedNRNo studies
Oral health education (advice and training) vs Standard care (oral health advice not specifically emphasised beyond usual care)
Quality of life: Chronic pain · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
No study reported useable data0 studiesNo studies
Motivational interview plus oral health education vs Oral health education
Oral health: Not brushing teeth twice a day · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
No study reported useable data0 studiesNo studies
Motivational interview plus oral health education vs Oral health education
Oral health: Not having seen a dentist in the past year · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per…
Oral health education (advice and training) for people with serious mental illness (2016) · Cochrane
No study reported useable data0 studiesNo studies
FLUPHENAZINE DECANOATE vs ORAL NEUROLEPTICS
Hospital admission ‐ not reported · patients with schizophrenia
Fluphenazine decanoate (depot) and enanthate for schizophrenia (2015) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE
Death ‐ not reported · patients with schizophrenia
Fluphenazine decanoate (depot) and enanthate for schizophrenia (2015) · Cochrane
no estimate extractedNRNo studies
FLUPHENAZINE DECANAOTE vs FLUPHENAZINE ENANTHATE
Clinically significant change in global state ‐ not reported · patients with schizophrenia
Fluphenazine decanoate (depot) and enanthate for schizophrenia (2015) · Cochrane
no estimate extractedNRNo studies