Gap finder
Search review questions
Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
587 questions in 116 reviews · Eyes and Vision
current versionsNo studies 587 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Hydrus microstent vs iStent trabecular micro‐bypass stent Visual field progression · people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma (2020) · Cochrane | no estimate extracted | NR | No studies |
Hydrus microstent vs iStent trabecular micro‐bypass stent Mean change in health‐related quality of life · people with open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled with medication Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma (2020) · Cochrane | no estimate extracted | NR | No studies |
Cataract surgery with Hydrus microstent vs cataract surgery alone Visual field progression · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled… Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma (2020) · Cochrane | no estimate extracted | NR | No studies |
Cataract surgery with Hydrus microstent vs cataract surgery alone Mean change in health‐related quality of life · people with cataracts and open angle glaucoma, many of whom had mild or moderate glaucoma, which was well‐controlled… Ab interno trabecular bypass surgery with Schlemm´s canal microstent (Hydrus) for open angle glaucoma (2020) · Cochrane | no estimate extracted | NR | No studies |
Fenretinide vs placebo Proportion of participants losing ≥ 10 EDTRS letters · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Fenretinide vs placebo Progression to advanced AMD (geographic atrophy or neovascular) · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Fenretinide vs placebo Mean change in macular sensitivity · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Emixustat vs placebo Proportion of participants losing ≥ 10 EDTRS letters** · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Emixustat vs placebo Progression to advanced AMD (geographic atrophy or neovascular) · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Emixustat vs placebo Mean change in macular sensitivity · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Fenretinide vs placebo Proportion of participants losing ≥ 15 EDTRS letters · people with geographic atrophy due to AMD Visual cycle modulators versus placebo or observation for the prevention and treatment of geographic atrophy… (2020) · Cochrane | no estimate extracted | NR | No studies |
Oral azithromycin vs control Ocular C trachomatis infection · people (any age) with active trachoma Antibiotics for trachoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral azithromycin vs topical tetracycline Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic · people (any age) with active trachoma Antibiotics for trachoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Antibiotic vs control Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic · people (any age) with active trachoma Antibiotics for trachoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral vs topical antibiotic Antibiotic resistance Proportion of samples showing evidence of resistance to antibiotic · people (any age) with active trachoma Antibiotics for trachoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral azithromycin vs control Active trachoma Clinical assessment: active trachoma defined as TF, TI, or both · people (any age) with active trachoma Antibiotics for trachoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Summary of findings: anti‐VEGF treatment vs control Reduction in central retinal thickness at 1 year · people with neovascular age‐related macular degeneration Anti‐vascular endothelial growth factor for neovascular age‐related macular degeneration (2019) · Cochrane | no estimate extracted | NR | No studies |
Routine preoperative medical testing vs selective or no testing Clinical management changes (other than cancellation) prior to surgery · adults with age‐related cataract Routine preoperative medical testing for cataract surgery (2019) · Cochrane | no estimate extracted | NR | No studies |
Routine preoperative medical testing vs selective or no testing Quality of life outcomes at any · adults with age‐related cataract Routine preoperative medical testing for cataract surgery (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy alone Change in ocular surface staining at 1‐month · people with dry eyea Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy alone Change in Schirmer test (aqueous tear production, measured in mm/5 min) at 1‐month of · people with dry eyea Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy alone Change in tear film stability, measured using tear break‐up time (TBUT) with fluorescein (in seconds) at 1‐month · people with dry eyea Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy alone Change in tear osmolarity (measured in mOsmol/L, with reductions in osmolarity indicating clinical improvement) at 1‐month · people with dry eyea Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy alone Adverse events at 1‐month · people with dry eyea Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Aqueous shunts with vs without mitomycin C Control of IOP, assessed as the mean decrease in IOP from baseline · adults with glaucoma requiring aqueous shunt surgery Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Aqueous shunts with vs without mitomycin C Mean change from baseline in visual acuity · adults with glaucoma requiring aqueous shunt surgery Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Aqueous shunts with vs without mitomycin C Proportion of participants with stable best‐corrected visual acuity · adults with glaucoma requiring aqueous shunt surgery Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Aqueous shunts with vs without mitomycin C Proportion of participants with decreased visual acuity · adults with glaucoma requiring aqueous shunt surgery Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Aqueous shunts with vs without mitomycin C Proportion of participants with a postoperative hypertensive phase · adults with glaucoma requiring aqueous shunt surgery Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Endoscopic cyclophotocoagulation vs the Ahmed drainage implant Pain control change from baseline 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Micropulse vs continuous‐wave cyclophotocoagulation Mean change in the mean deviation in study eyes change from baseline 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Micropulse vs continuous‐wave cyclophotocoagulation Mean change in quality of life scores 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Pain control change from baseline 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mean change in the mean deviation in study eyes change from baseline 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mean number of glaucoma medications 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Adverse events 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mean change in quality of life scores 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mean change in the mean deviation in study eyes change from baseline 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Intervention NR Mean change in quality of life scores 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Endoscopic cyclophotocoagulation vs the Ahmed drainage implant Mean change in mean deviation in study eyes 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Endoscopic cyclophotocoagulation vs the Ahmed drainage implant Mean change in quality of life scores 12 months postintervention · adults with refractory glaucoma Cyclodestructive procedures for refractory glaucoma (2019) · Cochrane | no estimate extracted | NR | No studies |
Autogenous fascia vs Gore‐Tex Economic outcomes ‐ not measured · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Autogenous fascia vs Gore‐Tex Quality of life ‐ not measured · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Mersilene mesh vs autogenous fascia Functional success of surgery ‐ not reported · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Mersilene mesh vs autogenous fascia Sling removal ‐ not reported · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Mersilene mesh vs autogenous fascia Infection ‐ not reported · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Mersilene mesh vs autogenous fascia Economic outcomes ‐ not reported · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Mersilene mesh vs autogenous fascia Quality of life ‐ not reported · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Gore‐Tex vs Ethibond Economic outcomes ‐ not measured · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |
Gore‐Tex vs Ethibond Quality of life ‐ not measured · frontalis sling surgery for congenital ptosis Types of materials for frontalis sling surgery for congenital ptosis (2019) · Cochrane | no estimate extracted | NR | No studies |