Search review questions

CI: confidence interval · adults with PPPD

Improvement in vertigo at 3 to ≤ 6 months · adults with PPPD

Change in vertigo at 3 to ≤ 6 months · adults with PPPD

Potency/bioactivity parameters of human insulin · healthy physicians

Diabetic ketoacidosis · healthy physicians

Hypoglycaemic episodes · healthy physicians

Adverse events · healthy physicians

Health‐related quality of life · healthy physicians

HbA1c · healthy physicians

Viral clearance at 14 days · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression…

Participants with new need for invasive mechanical ventilation or death · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Participants discharged alive. Participants should be discharged without clinical deterioration or death · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Quality of life up to 28 days and longest · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

SAEs during the study period · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Any grade TEAE · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Any grade TRAE · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Discontinuation of study drug due to adverse events · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Viral clearance · hospitalized people with mild to moderate symptomatic COVID‐19 (WHO scale 2 to 4) with severe comorbidities

Admission to ICU or death · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression…

All initial symptoms resolved at 28 days, and up to the longest · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression…

Time to symptom resolution · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression…

Quality of life up to 28 days and longest · unvaccinated, non‐hospitalized people with mild symptomatic COVID‐19 (WHO scale 2 to 3) at high risk for progression…

Seizures (clinically diagnosed) · preterm infants

Moderate to severe neurodevelopmental disability at 18 to 26 months · preterm infants

a) Cerebral palsy · preterm infants

b) Gross motor disability defined as ≥ level 2 according to the GMFCS · preterm infants

d) Mental development IQ > 2 SD below the mean · preterm infants

Evidence from RCTs · hospitalized, mechanically ventilated adults with confirmed SARS‐CoV‐2 infection

Mortality · hospitalized, mechanically ventilated adults with confirmed SARS‐CoV‐2 infection

Need for renal replacement therapy · hospitalized, mechanically ventilated adults with confirmed SARS‐CoV‐2 infection

Evidence from NRSIs · hospitalized, mechanically ventilated adults with confirmed SARS‐CoV‐2 infection

Episodes of bradycardia, defined as a fall in heart rate of more than 30% below the baseline or less than 100 beats per minute for 10 seconds or longer— not reported · lumbar puncture in newborn infants

Time to perform the lumbar puncture—not reported · lumbar puncture in newborn infants

Episodes of desaturation, defined as a decrease of SpO2 to less than 80%, with no minimum duration specified—not reported · lumbar puncture in newborn infants

Apnea: number of episodes (defined as interruption of breathing for more than 20 seconds) during the procedure—not reported · lumbar puncture in newborn infants

Apnea: number of infants with 1 or more episodes (defined as interruption of breathing for more than 20 seconds) during the procedure—not reported · lumbar puncture in newborn infants

Total number of lumbar puncture attempts (successful or unsuccessful)—not reported · lumbar puncture in newborn infants

Apnea: number of infants with 1 or more episodes (defined as interruption of breathing for more than 20 seconds) during the procedure—not reported · lumbar puncture in newborn infants

Total number of lumbar puncture attempts—not reported · lumbar puncture in newborn infants

Apnea: number of episodesduring the procedure · newborn infants undergoing lumbar puncture

Bibliometric scores · peer reviewers

Adverse effects on oral health: bleeding on probing (lower arch) · People who had received fixed appliance orthodontic treatment · 12 months, lower arch

Total mortality · Adults with oral cavity cancer (tongue or floor of mouth) and clinically negative neck nodes

Total number of orthodontic appliance adjustment appointments during treatment · Adolescents and adults with malocclusion undergoing fixed orthodontic appliance treatment

Disease-free survival · Adults with oral cavity or oropharyngeal cancer

Patient satisfaction: discomfort/pain (lower arch) · People who had received fixed appliance orthodontic treatment · 12 months, lower arch

Recurrence · Adults with oral cavity or oropharyngeal cancer · oral cavity

Survival: mean survival time (lower arch, months) · People who had received fixed appliance orthodontic treatment · 12 months, lower arch

Recurrence · Adults with oropharyngeal cancer

Not applicable (no eligible studies) · Adults with coronal (crown) dental caries in permanent teeth