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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
302 questions in 48 reviews · Neuromuscular
current versionsNo studies 302 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Respiratory muscle training vs sham training Measures of lung capacity over the long term (greater than 1 year) · people with ALS Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs breathing exercises Measures of lung capacity over the medium term (greater than 3 months but less than 1 year) · people with myasthenia gravis Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs breathing exercises Measures of lung capacity over the long term (greater than 1 year) · people with myasthenia gravis Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs breathing exercises Physical function in carrying out activities of daily living · people with myasthenia gravis Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs breathing exercises Number of unscheduled hospitalizations for episodes of chest infection or acute exacerbation of chronic respiratory failure within 1 year of randomization · people with myasthenia gravis Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs breathing exercises All adverse events · people with myasthenia gravis Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs sham training Number of unscheduled hospitalisations for episodes of chest infection or acute exacerbation of chronic respiratory failure within 1 year of randomization · people with ALS Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Respiratory muscle training vs sham training Measures of lung capacity over the medium term (greater than 3 months but less than 1 year) · children and young males with DMD Respiratory muscle training in children and adults with neuromuscular disease (2019) · Cochrane | no estimate extracted | NR | No studies |
BM‐MSC vs no treatment Functional impairment, assessed using a functional rating scale (change from baseline to 12 months) · people with probable or definite amyotrophic lateral sclerosis/motor neuron disease (treated with riluzole) Cell‐based therapies for amyotrophic lateral sclerosis/motor neuron disease (2019) · Cochrane | no estimate extracted | NR | No studies |
BM‐MSC vs no treatment Muscle strength: manual muscle testing (mean change from baseline to 12 months) · people with probable or definite amyotrophic lateral sclerosis/motor neuron disease (treated with riluzole) Cell‐based therapies for amyotrophic lateral sclerosis/motor neuron disease (2019) · Cochrane | no estimate extracted | NR | No studies |
Combined strength and aerobic exercise training vs usual care Physical activity ‐ change from baseline · children and adults with SMA type 3 Physical exercise training for type 3 spinal muscular atrophy (2019) · Cochrane | no estimate extracted | NR | No studies |
Botulinum toxin plus conservative treatment vs conservative treatment only Active range of motion of the ankle joint · children with ITW gait Interventions for idiopathic toe walking (2019) · Cochrane | no estimate extracted | NR | No studies |
Botulinum toxin plus conservative treatment vs conservative treatment only Pain · children with ITW gait Interventions for idiopathic toe walking (2019) · Cochrane | no estimate extracted | NR | No studies |
Idebenone (3 daily tablets of 150 mg) vs placebo Size of metabolically abnormal areas of myocardium · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Idebenone (3 daily tablets of 150 mg) vs placebo Improvements in quality of life measures · boys (aged 8 to 16 years old) with subclinical cardiomyopathy in DMD Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Eplerenone (25 mg daily) vs placebo Improvements in quality of life measures · boys with DMD and left ventricular ejection fraction 45% or more Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Prophylactic perindopril (2 mg to 4 mg daily) vs placebo Size of metabolically abnormal areas of myocardium · boys with DMD, normal cardiac examination and LVEF > 55% at baseline Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Growth hormone (0.23 mg/kg/week for DMD and 0.07 mg/kg/week in BMD SC injection) vs placebo Size of metabolically abnormal areas of myocardium · people with DMD or BMD (ages not stated) Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Growth hormone (0.23 mg/kg/week for DMD and 0.07 mg/kg/week in BMD SC injection) vs placebo Improvements in quality of life measures · people with DMD or BMD (ages not stated) Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Prophylactic perindopril (2 mg to 4 mg daily) vs placebo Improvements in quality of life measures · boys with DMD, normal cardiac examination and LVEF > 55% at baseline Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Lisinopril (0.7 mg/kg daily) vs losartan (0.7 mg/kg daily) Size of metabolically abnormal areas of myocardium · patients with established cardiomyopathy in DMD Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Lisinopril (0.7 mg/kg daily) vs losartan (0.7 mg/kg daily) Improvements in quality of life measures · patients with established cardiomyopathy in DMD Interventions for preventing and treating cardiac complications in Duchenne and Becker muscular dystrophy… (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs gastrokinetic agents Changes of medication for gastroparesis (either short or long term) ‐ not measured · people with symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs gastrokinetic agents Quality of life (either short or long term) ‐ not measured · people with symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs non‐gastrokinetic agents Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs non‐gastrokinetic agents Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs non‐gastrokinetic agents Changes of medication for gastroparesis (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs non‐gastrokinetic agents Quality of life (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs non‐gastrokinetic agents Adverse events ‐ not reported · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus gastrokinetic agents vs gastrokinetic agents alone Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not reported · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus gastrokinetic agents vs gastrokinetic agents alone Changes of medication for gastroparesis (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus gastrokinetic agents vs gastrokinetic agents alone Quality of life (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Proportion of people whose symptoms 'improved' (short term: 4 to 12 weeks) ‐ not reported · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus non‐gastrokinetic agents vs non‐gastrokinetic agents alone Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not reported · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus non‐gastrokinetic agents vs non‐gastrokinetic agents alone Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus non‐gastrokinetic agents vs non‐gastrokinetic agents alone Changes of medication for gastroparesis (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus non‐gastrokinetic agents vs non‐gastrokinetic agents alone Quality of life (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus non‐gastrokinetic agents vs non‐gastrokinetic agents alone Adverse events ‐ not reported · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus routine care/diabetes control vs the same treatment alone (routine care/diabetes control) Improvement in symptoms of gastroparesis (short term: 4 to 12 weeks) · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus routine care/diabetes control vs the same treatment alone (routine care/diabetes control) Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus routine care/diabetes control vs the same treatment alone (routine care/diabetes control) Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus routine care/diabetes control vs the same treatment alone (routine care/diabetes control) Changes of medication for gastroparesis (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus routine care/diabetes control vs the same treatment alone (routine care/diabetes control) Quality of life (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture plus routine care/diabetes control vs the same treatment alone (routine care/diabetes control) Adverse events ‐ not reported · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Changes of medication for gastroparesis (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs sham acupuncture Quality of life (either short or long term) ‐ not measured · symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs gastrokinetic agents Improvement in symptoms of gastroparesis (long term: more than 12 weeks) ‐ not measured · people with symptomatic gastroparesis Acupuncture for symptomatic gastroparesis (2018) · Cochrane | no estimate extracted | NR | No studies |
Acupuncture vs vitamin B12 Overall clinical improvement at long‐term · carpal tunnel syndrome Acupuncture and related interventions for the treatment of symptoms associated with carpal tunnel syndrome (2018) · Cochrane | no estimate extracted | NR | No studies |