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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

240 questions in 36 reviews · Dementia and Cognitive Improvement

current versions
No studies 240 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
NaoMaiTai vs Western medicine
Cognition‐ADAS‐Cog ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
NaoMaiTai vs Western medicine
Global performance (improved) ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
FuFangDanShen vs 'no treatment'
Global performance (improved) ‐ not measured · people with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
NaoMaiTai vs Western medicine
Activities of Daily Living (ADL) ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
NaoMaiTai vs Western medicine
Behaviour ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
NaoXinTong vs Western medicine
Cognition‐ADAS‐Cog ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
NaoXinTong vs Western medicine
Behaviour ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
QingKaiLing vs Western medicine
Cognition‐MMSE ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
QingKaiLing vs Western medicine
Cognition‐ADAS‐Cog ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
QingKaiLing vs Western medicine
Global performance (improved) ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
QingKaiLing vs Western medicine
Adverse events (AEs) (one or more events) ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
QingKaiLing vs Western medicine
Activities of Daily Living (ADL) ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
QingKaiLing vs Western medicine
Behaviour ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
ShenFuTang vs Western medicine
Cognition‐HDS ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
ShenFuTang vs Western medicine
Cognition‐ADAS‐Cog ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
ShenFuTang vs Western medicine
Global performance (improved) ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
ShenFuTang vs Western medicine
Behaviour ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
TongXingLuo vs Western medicine
Cognition‐HDS ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
TongXingLuo vs Western medicine
Cognition‐ADAS‐Cog ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
TongXingLuo vs Western medicine
Activities of Daily Living (ADL) ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
FuFangDanShen vs 'no treatment'
Behaviour ‐ not measured · people with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
TongXingLuo vs Western medicine
Behaviour ‐ only measured in one study · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
FuFangHaiShe vs 'no treatment'
Cognition‐HDS ‐ not measured · People with vascular dementia
Traditional Chinese herbal medicine for vascular dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for spaced retrieval combined with errorless learning training programme for people with dementia vs spaced retrieval only training programme
Nutritional status not measured · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for spaced retrieval combined with errorless learning training programme for people with dementia vs spaced retrieval only training programme
Mealtime behaviour not measured · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for spaced retrieval combined with errorless learning training programme for people with dementia vs spaced retrieval only training programme
CI: confidence interval · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for feeding skills training programme for nurses vs no intervention
Nutritional status not measured · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for additional food items between meals vs usual care
Mealtime behaviour not measured · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for verbal and physical encouragement by touch vs only verbal encouragement during meals
Nutritional status not measured · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
Summary of findings for verbal and physical encouragement by touch vs only verbal encouragement during meals
Mealtime behaviour not measured · people with dementia
Environmental and behavioural modifications for improving food and fluid intake in people with dementia (2018) · Cochrane
no estimate extractedNRNo studies
B vitamins vs placebo
Incidence of dementia ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E vs placebo
Quality of life ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E + vitamin C vs placebo
Incidence of dementia ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E + vitamin C vs placebo
Episodic memory ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E + vitamin C vs placebo
Executive function ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E + vitamin C vs placebo
Speed of processing ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E + vitamin C vs placebo
Quality of life ‐ not measured · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E + vitamin C vs placebo
Mortality ‐ not reported · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
B vitamins vs placebo
Mortality ‐ not reported · MCI
Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with… (2018) · Cochrane
no estimate extractedNRNo studies
Complex multivitamin vs control
Incidence of MCI or all‐cause dementia ‐ not measured · cognitively healthy people in mid and late life
Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid… (2018) · Cochrane
no estimate extractedNRNo studies
Modafinil vs placebo
Adverse Events ‐ reported, but not analyzed in this review · Apathy in people with mild‐to‐moderate Alzheimer's disease
Pharmacological interventions for apathy in Alzheimer's disease (2018) · Cochrane
no estimate extractedNRNo studies
Modafinil vs placebo
Change in NPS ‐ not investigated · Apathy in people with mild‐to‐moderate Alzheimer's disease
Pharmacological interventions for apathy in Alzheimer's disease (2018) · Cochrane
no estimate extractedNRNo studies
Modafinil vs placebo
Change in cognition ‐ not investigated · Apathy in people with mild‐to‐moderate Alzheimer's disease
Pharmacological interventions for apathy in Alzheimer's disease (2018) · Cochrane
no estimate extractedNRNo studies
Modafinil vs placebo
Change in global disease severity ‐ not investigated · Apathy in people with mild‐to‐moderate Alzheimer's disease
Pharmacological interventions for apathy in Alzheimer's disease (2018) · Cochrane
no estimate extractedNRNo studies
Modafinil vs placebo
Dropouts ‐ reported, but not analyzed in this review · Apathy in people with mild‐to‐moderate Alzheimer's disease
Pharmacological interventions for apathy in Alzheimer's disease (2018) · Cochrane
no estimate extractedNRNo studies
Cholinesterase inhibitors (rivastigmine) vs placebo
Severity of delirium CAM negative · people with delirium
Cholinesterase inhibitors for the treatment of delirium in non‐ICU settings (2018) · Cochrane
no estimate extractedNRNo studies
Cholinesterase inhibitors (rivastigmine) vs placebo
Persistent cognitive impairment · people with delirium
Cholinesterase inhibitors for the treatment of delirium in non‐ICU settings (2018) · Cochrane
no estimate extractedNRNo studies
Cholinesterase inhibitors (rivastigmine) vs placebo
Length of hospitalisation · people with delirium
Cholinesterase inhibitors for the treatment of delirium in non‐ICU settings (2018) · Cochrane
no estimate extractedNRNo studies
Cholinesterase inhibitors (rivastigmine) vs placebo
Cost of intervention · people with delirium
Cholinesterase inhibitors for the treatment of delirium in non‐ICU settings (2018) · Cochrane
no estimate extractedNRNo studies
Vitamin E (capsules 2000 IU/day in two divided doses) vs placebo
Cognitive function Mean change from baseline of ADAS‐Cog Scale from: 0 to 70 · people with mild cognitive impairment
Vitamin E for Alzheimer's dementia and mild cognitive impairment (2017) · Cochrane
no estimate extractedNRNo studies