What do systematic reviews say?

Relief of pain · children with acute postoperative pain

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Serious adverse events, defined as any medical event at any dose that results in death, is life‐threatening, requires hospitalisation (or prolongation of existing hospitalisation) or results in permanent damage or disability (FDA 2016) · children with acute postoperative pain

Relief of pain · children with acute postoperative pain

Frequency of intervention‐related non‐ocular adverse events ( · people with primary macula‐involving rhegmatogenous retinal detachments

Hospital stay — not reported · patients requiring haemodialysis

Hospital stay — not reported · patients requiring haemodialysis

Virologically confirmed dengue case incidence (any severity, any phenotype) · children and adults at risk of dengue infection

Prevalence of dengue RNA in the mosquito population · children and adults at risk of dengue infection

Mosquito density (for population suppression strategy) · children and adults at risk of dengue infection

Prevalence of Wolbachia‐carrying mosquitoes (for population replacement strategy) · children and adults at risk of dengue infection

Adverse events potentially related to Wolbachia‐carrying Aedes deployments · children and adults at risk of dengue infection

Participant satisfaction · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Muscle pain at rest · People with temporomandibular disorders (TMD)

Caries arrest · Children and adults (with or without carious lesions)

Outcome not reported · Adults with symptomatic apical periodontitis or acute apical abscess

Improvement in range of jaw movement · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)

Time to alignment · People receiving orthodontic treatment with fixed appliances (upper and/or lower full arch)

Quality of life · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)