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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Limit to evidence status or GRADE (optional)

587 questions in 116 reviews · Eyes and Vision

current versions
No studies 587 · 100%Ungraded 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

QuestionEffectEvidenceStatus / GRADE
Rho kinase inhibitor vs beta‐blocker
Glaucoma progression at 12 months, defined by anatomic (structural) criteriab · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs beta‐blocker
Patient‐reported outcome at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs beta‐blocker
Mean change in the number of glaucoma medications at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs beta‐blocker
Need for additional treatment at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs prostaglandin analog
Glaucoma progression at 12 months, measured by additional visual field defects · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs prostaglandin analog
Glaucoma progression at 12 months, defined by anatomic (structural) criteriab · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs prostaglandin analog
Patient‐reported outcome at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs prostaglandin analog
Mean change in the number of glaucoma medications at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs prostaglandin analog
Need for additional treatment at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs prostaglandin analoga
Glaucoma progression at 12 months, measured by additional visual field defects · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs prostaglandin analoga
Glaucoma progression at 12 months, defined by anatomic (structural) criteriab · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs prostaglandin analoga
Patient‐reported outcome at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs prostaglandin analoga
Mean change in the number of glaucoma medications at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs prostaglandin analoga
Need for additional treatment at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs rho kinase inhibitor
Glaucoma progression at 12 months, measured by additional visual field defects · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs placeboa
Glaucoma progression at 12 months, defined by anatomic (structural) criteriad · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs rho kinase inhibitor
Glaucoma progression at 12 months, defined by anatomic (structural) criteriab · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs rho kinase inhibitor
Patient‐reported outcome at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs rho kinase inhibitor
Mean change in the number of glaucoma medications at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and prostaglandin analog vs rho kinase inhibitor
Need for additional treatment at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and beta‐blocker vs beta‐blocker
Glaucoma progression at 12 months, measured by additional visual field defects · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and beta‐blocker vs beta‐blocker
Glaucoma progression at 12 months, defined by anatomic (structural) criteriab · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and beta‐blocker vs beta‐blocker
Patient‐reported outcome at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs placeboa
Patient‐reported outcome at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and beta‐blocker vs beta‐blocker
Mean change in the number of glaucoma medications at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor and beta‐blocker vs beta‐blocker
Need for additional treatment at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs placeboa
Mean change in the number of glaucoma medications at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs placeboa
Need for additional treatment at the longest · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Rho kinase inhibitor vs beta‐blocker
Glaucoma progression at 12 months, measured by additional visual field defects · people with primary open‐angle glaucoma or ocular hypertension
Rho kinase inhibitor for primary open‐angle glaucoma and ocular hypertension (2022) · Cochrane
no estimate extractedNRNo studies
Topical antibiotics vs another topical antibiotic or placebo
Change in pain intensity from baseline to 1 month · children and adults with corneal abrasion
Antibiotic prophylaxis for corneal abrasion (2022) · Cochrane
no estimate extractedNRNo studies
Topical antibiotics vs another topical antibiotic or placebo
Recurrent corneal erosion within 1 year · children and adults with corneal abrasion
Antibiotic prophylaxis for corneal abrasion (2022) · Cochrane
no estimate extractedNRNo studies
Topical antibiotics vs another topical antibiotic or placebo
Change in visual acuity from baseline to 1 year, or loss of 1 or more lines of best‐corrected visual acuity at 1 month · children and adults with corneal abrasion
Antibiotic prophylaxis for corneal abrasion (2022) · Cochrane
no estimate extractedNRNo studies
Topical antibiotics vs another topical antibiotic or placebo
Quality of life at 1 month · children and adults with corneal abrasion
Antibiotic prophylaxis for corneal abrasion (2022) · Cochrane
no estimate extractedNRNo studies
Steroids with or without azathioprine vs cyclosporine A
Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU
Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults (2022) · Cochrane
no estimate extractedNRNo studies
Steroids with or without azathioprine vs cyclosporine A
Proportion of participants with confirmed macular edema (lower number of events is better) · NIIPPU
Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults (2022) · Cochrane
no estimate extractedNRNo studies
Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroid
Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) Â · NIIPPU
Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults (2022) · Cochrane
no estimate extractedNRNo studies
Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroid
Proportion of participants with confirmed macular edema (lower number of events is better) · NIIPPU
Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults (2022) · Cochrane
no estimate extractedNRNo studies
Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroid
Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU
Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults (2022) · Cochrane
no estimate extractedNRNo studies
Methotrexate vs mycophenolate
Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU
Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults (2022) · Cochrane
no estimate extractedNRNo studies
Steroids vs cyclosporine A
Adverse effect: new cataract formation · people with dry eye
Topical corticosteroids for dry eye (2022) · Cochrane
no estimate extractedNRNo studies
Steroids vs lubricants
Change in patient‐reported quality of life scores · people with dry eye
Topical corticosteroids for dry eye (2022) · Cochrane
no estimate extractedNRNo studies
Steroids vs cyclosporine A
Change in patient‐reported quality of life scores · people with dry eye
Topical corticosteroids for dry eye (2022) · Cochrane
no estimate extractedNRNo studies
Patching vs active observation
Stereoacuity at distance Loss of ≥ 2 octaves near stereoacuity, measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged less than 11 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Patching vs active observation
Motor fusion test · people with intermittent exotropia, aged less than 11 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Patching vs active observation
Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged less than 11 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Patching vs active observation
Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged less than 11 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Prism adaptation test with eye muscle surgery vs eye muscle surgery alone
Motor alignment at near fixation Measured using PACT at 6 months · people with intermittent exotropia, aged 5 to 49 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Prism adaptation test with eye muscle surgery vs eye muscle surgery alone
Stereoacuity at near · people with intermittent exotropia, aged 5 to 49 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Prism adaptation test with eye muscle surgery vs eye muscle surgery alone
Stereoacuity at distance Measured using the Preschool Randot test 3 years after surgery · people with intermittent exotropia, aged 5 to 49 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies
Prism adaptation test with eye muscle surgery vs eye muscle surgery alone
Motor alignment at distance fixation Measured using PACT at 6 months · people with intermittent exotropia, aged 5 to 49 years
Interventions for intermittent exotropia (2021) · Cochrane
no estimate extractedNRNo studies